ArticleScience signaling2016
Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.
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In one paragraph
Article in Science signaling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Even breathing gets old: Impact of ageing on small arteries of the diaphragm.The Journal of physiology · 2025Article
- Uncoupling of CaProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Role of Oxidants in Percutaneous Coronary Intervention-Induced Endothelial Dysfunction: Can We Harness Redox Signaling to Improve Clinical Outcomes?Antioxidants & redox signaling · 2023Review
- Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases.Molecules (Basel, Switzerland) · 2023Review
- Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases.Frontiers in pharmacology · 2022Review
- Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation.Nature communications · 2021Article
- Uteroplacental Circulation in Normal Pregnancy and Preeclampsia: Functional Adaptation and Maladaptation.International journal of molecular sciences · 2021Review
- Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.Comprehensive Physiology · 2021Article
- Ryanodine receptor subtypes regulate Ca2+ sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy.Cardiovascular research · 2021Article
- Extra Virgin Olive Oil Phenols Vasodilate Rat MesentericResistance Artery via Phospholipase C (PLC)-CalciumMicrodomains-Potassium Channels (BKBiomolecules · 2021Article
- Effects of Pharmacological Inhibitors of NADPH Oxidase on Myogenic Contractility and Evoked Vasoactive Responses in Rat Resistance Arteries.Frontiers in physiology · 2021Article
- Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of CaHypertension (Dallas, Tex. : 1979) · 2020Article
- Disruption of Pressure-Induced CaHypertension (Dallas, Tex. : 1979) · 2020Article
- "A Step and a Ceiling": mechanical properties of CaPhysiological reports · 2019Article
- Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Pregnancy Increases CaHypertension (Dallas, Tex. : 1979) · 2019Article
- Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase.The Journal of biological chemistry · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Kaivan Khavandi *Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, M13 9NT, UK.
Rachael A Baylie *Institute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, M13 9NT, UK.
Sarah A SugdenInstitute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, M13 9NT, UK.
Majid AhmedInstitute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, M13 9NT, UK.
Viktoria CsatoInstitute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, M13 9NT, UK.
Philip EatonKing's College London, Cardiovascular Division, The British Heart Foundation Centre of Excellence, The Rayne Institute, Saint Thomas' Hospital, London, SE1 7EH, UK.
David C Hill-EubanksDepartment of Pharmacology, University of Vermont, Vermont, 05405-0068, USA.
Adrian D BonevDepartment of Pharmacology, University of Vermont, Vermont, 05405-0068, USA.
Mark T NelsonInstitute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, M13 9NT, UK.
Adam S GreensteinInstitute of Cardiovascular Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Center, Manchester, M13 9NT, UK.
University of Vermont · US
Funding
Impact of SAH on Parenchymal Arterioles and Neurovascular CouplingP01HL095488 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BONEV, ADRIAN · 2010 to 2014
$11.4MCa2+ Sparks and Urinary Bladder Smooth Muscle ExcitabilityR37DK053832 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2008 to 2017
$3.4MCA++ SPARKS &URINARY BLADDER SMOOTH MUSCLE EXCITABILITYR01DK053832 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI NELSON, MARK T · 1998 to 2006
$2.0MRegulations of Myoendothelial Function By Signaling Microdomains in HypertensionR01HL121706 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2014 to 2017
$1.6MK+ sensing & electrical signaling by Kir channels in brain vasculatureR01HL131181 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2016 to 2018
$1.4MEndothelial KCa channels, Ca2+ signaling & arteriolar function in the brainR01HL098243 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2010 to 2010
$269kBiotechnology and Biological Sciences Research Council BB/C503646/1British Heart Foundation FS/10/42/28372British Heart Foundation FS/11/45/28859British Heart Foundation FS/11/68/28821British Heart Foundation FS/12/81/29882British Heart Foundation FS/14/26/30767British Heart Foundation PG/10/98/28655British Heart Foundation PG/13/13/30018British Heart Foundation PG/15/109/31931British Heart Foundation PG/15/26/31373British Heart Foundation RG/12/12/29872Medical Research Council G0600785Medical Research Council G0700320Medical Research Council G1000458Medical Research Council MR/K003232/1Medical Research Council MR/L009684/1NHLBI NIH HHS P01 HL095488NHLBI NIH HHS R01 HL098243NHLBI NIH HHS R01 HL121706NHLBI NIH HHS R01 HL131181NIDDK NIH HHS R01 DK053832NIDDK NIH HHS R37 DK053832
Abstract
Activation of Ca
Indexed as
AnimalsBlood PressureCalcium SignalingCyclic GMP-Dependent Protein KinasesLarge-Conductance Calcium-Activated Potassium ChannelsMechanotransduction, CellularMiceMice, Mutant StrainsMuscle, Smooth, VascularMyocytes, Smooth MuscleVasoconstrictionCyclic GMP-Dependent Protein KinasesLarge-Conductance Calcium-Activated Potassium Channels
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.