ArticleProceedings of the National Academy of Sciences of the United States of America2016
Germline replications and somatic mutation accumulation are independent of vegetative life span in Arabidopsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 116 citations in OpenAlex.
- Somatic selection shapes mutation accumulation in Citrus sinensis.The Plant cell · 2026Article
- Millennial clonal persistence and transposable element-biased somatic mutations in an herbaceous plant (Typha latifolia).Communications biology · 2026Article
- Mapping the zygote-to-adult developmental cell phylogeny in Arabidopsis thaliana reveals a three-cell rule of branching.Nature plants · 2026Article
- Nanorate sequencing reveals theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Minimizing detection bias of somatic mutations in a highly heterozygous oak genome.G3 (Bethesda, Md.) · 2025Article
- Cytoplasmic inheritance: The transmission of plastid and mitochondrial genomes across cells and generations.Plant physiology · 2025Review
- Genome sequencing of 'Fuji' apple clonal varieties reveals genetic mechanism of the spur-type morphology.Nature communications · 2024Article
- Article
- Exploring the Relationship Between Gene Expression and Low-Frequency Somatic Mutations in Arabidopsis with Duplex Sequencing.Genome biology and evolution · 2024Article
- Heteroplasmy Is Rare in Plant Mitochondria Compared with Plastids despite Similar Mutation Rates.Molecular biology and evolution · 2024Article
- Male Germ Cell Specification in Plants.International journal of molecular sciences · 2024Review
- Growing old while staying young : The unique mechanisms that defy aging in plants.EMBO reports · 2024Article
- Temporal regulation of vegetative phase change in plants.Developmental cell · 2024Review
- Stochastic organelle genome segregation through Arabidopsis development and reproduction.The New phytologist · 2024Article
- Evolutionary features of microspore and pollen grain development in Cyperaceae.Plant reproduction · 2023Article
- Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space.Nature communications · 2023Article
- Tropical Trees Will Need to Acclimate to Rising Temperatures-But Can They?Plants (Basel, Switzerland) · 2023Review
- Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis.BMC plant biology · 2023Article
- DNA methylation dynamics during germline development.Journal of integrative plant biology · 2022Review
- Sorting of mitochondrial and plastid heteroplasmy inProceedings of the National Academy of Sciences of the United States of America · 2022Article
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8 authors at 2 institutions in 2 countries.
Funding
Abstract
In plants, gametogenesis occurs late in development, and somatic mutations can therefore be transmitted to the next generation. Longer periods of growth are believed to result in an increase in the number of cell divisions before gametogenesis, with a concomitant increase in mutations arising due to replication errors. However, there is little experimental evidence addressing how many cell divisions occur before gametogenesis. Here, we measured loss of telomeric DNA and accumulation of replication errors in Arabidopsis with short and long life spans to determine the number of replications in lineages leading to gametes. Surprisingly, the number of cell divisions within the gamete lineage is nearly independent of both life span and vegetative growth. One consequence of the relatively stable number of replications per generation is that older plants may not pass along more somatically acquired mutations to their offspring. We confirmed this hypothesis by genomic sequencing of progeny from young and old plants. This independence can be achieved by hierarchical arrangement of cell divisions in plant meristems where vegetative growth is primarily accomplished by expansion of cells in rapidly dividing meristematic zones, which are only rarely refreshed by occasional divisions of more quiescent cells. We support this model by 5-ethynyl-2'-deoxyuridine retention experiments in shoot and root apical meristems. These results suggest that stem-cell organization has independently evolved in plants and animals to minimize mutations by limiting DNA replication.
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