Evidence map›Paper›PMID 27729459›Full record

Observational studyClinical cancer research : an official journal of the American Association for Cancer Research2017

Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum.

Alicia Hulbert, Ignacio Jusue-Torres, Alejandro Stark, Chen Chen, Kristen Rodgers, Beverly Lee, Candace Griffin, Andrew Yang, Peng Huang, John Wrangle and 6 more

Registry-linked trialOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06476067 (Predicting Postoperative Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma), which is not on this map. Cited by 179 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 6 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06476067 recruitingnot on this map

Predicting Postoperative Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma

TypeobservationalSponsorCity of Hope Medical CenterRan2006 to 2028Enrolled150ConditionsEsophageal Cancer, Recurrence, DNA MethylationArmsSurgery
3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 6 syntheses or guidelines pooled it, 289 citations in OpenAlex.

  1. Clinical value of combinedOncology reviews · 2026
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119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Alicia HulbertSidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ignacio Jusue-TorresDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Alejandro StarkDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, Maryland.
Chen ChenSidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Kristen RodgersDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Beverly LeeDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Candace GriffinDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Andrew YangDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Peng HuangSidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
John WrangleDepartment of Medicine, Medical University of South Carolina, Charleston, South Carolina.
Steven A BelinskyLung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.
Tza-Huei WangSidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Stephen C YangDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Stephen B BaylinSidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Malcolm V BrockSidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
James G HermanSidney Kimmel Cancer Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. hermanj3@upmc.edu.
Johns Hopkins University · USCentral South University · CNLovelace Respiratory Research Institute · USMedical University of South Carolina · US

Funding

TARGETING EARLY CHANGES FOR NEW SCREENING STRATEGIESP50CA058184 · NCI · JOHNS HOPKINS UNIVERSITY · PI BISWAL, SHYAM · 1992 to 2013
$30.5M
NCI NIH HHS P50 CA058184
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationPromoter Regions, GeneticAgedArea Under CurveBiomarkers, TumorCarcinoma, Non-Small-Cell LungCase-Control StudiesDNAEarly Detection of CancerFemaleGene Expression ProfilingHumansLung NeoplasmsMaleMiddle AgedReal-Time Polymerase Chain ReactionBiomarkers, TumorDNA

Identifiers

PMID27729459
PMCPMC6366618
OpenAlexW2531153177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.