ArticleThe EMBO journal2016
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.
Registry-linked trialAbstract read
In one paragraph
Article in The EMBO journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07778641 (Genetic Study of OTOF- Related Auditory Neuropathy Spectrum Disorder), which is not on this map. Cited by 60 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Study of OTOF- Related Auditory Neuropathy Spectrum Disorder
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive functional network analysis and screening of deleterious pathogenic variants in non-syndromic hearing loss causative genes.Bioscience reports · 2021Pooled it
- FDA Approval of the Congenital OTOF Gene Therapy Otarmeni Reshapes the Future of Hearing Care.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness.Nature communications · 2026Article
- Electrophysiological and histological study reveals hidden subclinical haploinsufficiency ofGenes & diseases · 2026Article
- Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing.Science advances · 2025Article
- Structural insights into lipid membrane binding by human ferlins.The EMBO journal · 2025Article
- Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model.Communications medicine · 2025Article
- [The natural history of the relationship betweenLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Review
- UtilizingJournal of developmental biology · 2025Review
- Integrating multi-dimensional data to reveal the mechanisms and molecular targets of baikening granules for treatment of pediatric influenza.Frontiers in molecular biosciences · 2025Article
- CaBP1 and 2 enable sustained CaeLife · 2024Article
- Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells.bioRxiv : the preprint server for biology · 2024Article
- DMXL2 Is Required for Endocytosis and Recycling of Synaptic Vesicles in Auditory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing.Protein & cell · 2024Article
- The natural history, clinical outcomes, and genotype-phenotype relationship of otoferlin-related hearing loss: a systematic, quantitative literature review.Human genetics · 2023Review
- Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.EMBO reports · 2023Article
- Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform.Nature communications · 2023Article
- Temperature-Sensitive Auditory Neuropathy: Report of a Novel Variant of OTOF Gene and Review of Current Literature.Medicina (Kaunas, Lithuania) · 2023Article
- Age-dependent structural reorganization of utricular ribbon synapses.Frontiers in cell and developmental biology · 2023Article
- Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023Review
Corrections and comments
- Commented on by
Authors and funding
15 authors.
Nicola StrenzkeAuditory Systems Physiology Group, Department for Otolaryngology and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany nstrenzke@med.uni-goettingen.de carolin.wichmann@med.uni-goettingen.de ellen.reisinger@med.uni-goettingen.de.
Rituparna ChakrabartiCollaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", Göttingen, Germany.
Hanan Al-MoyedGöttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, Göttingen, Germany.
Alexandra MüllerCollaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", Göttingen, Germany.
Gerhard HochInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen and German Primate Center, Göttingen, Germany.
Tina PangrsicCollaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", Göttingen, Germany.
Gulnara YamanbaevaAuditory Systems Physiology Group, Department for Otolaryngology and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.
Christof LenzBioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Kuan-Ting PanBioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Elisabeth AugeAuditory Systems Physiology Group, Department for Otolaryngology and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.
Ruth Geiss-FriedlanderDepartment of Molecular Biology, University Medical Center Göttingen, Göttingen, Germany.
Henning UrlaubCollaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", Göttingen, Germany.
Nils BroseCollaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", Göttingen, Germany.
Carolin WichmannCollaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", Göttingen, Germany nstrenzke@med.uni-goettingen.de carolin.wichmann@med.uni-goettingen.de ellen.reisinger@med.uni-goettingen.de.
Ellen ReisingerCollaborative Research Center 889 "Cellular Mechanisms of Sensory Processing", Göttingen, Germany nstrenzke@med.uni-goettingen.de carolin.wichmann@med.uni-goettingen.de ellen.reisinger@med.uni-goettingen.de.ORCID 0000-0003-3739-7569
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multi-C
Indexed as
Auditory FatigueMutation, MissenseAnimalsExocytosisHair Cells, AuditoryHumansMembrane ProteinsMiceMutant ProteinsProtein StabilitySynapsesTemperatureMembrane ProteinsMutant Proteinsotoferlin protein, mouseOTOF protein, humanauditory neuropathyhair cellhearing lossotoferlinribbon synapse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT07778641ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.