Evidence map›Paper›PMID 27729419›Full record

ArticleCirculation. Cardiovascular interventions2016

Injectable Shear-Thinning Hydrogels for Minimally Invasive Delivery to Infarcted Myocardium to Limit Left Ventricular Remodeling.

Christopher B Rodell, Madonna E Lee, Hua Wang, Satoshi Takebayashi, Tetsushi Takayama, Tomonori Kawamura, Jeffrey S Arkles, Neville N Dusaj, Shauna M Dorsey, Walter R T Witschey and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular interventions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.

  1. Pooled it
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  10. Hydrogels for Cardiac Tissue Regeneration: Current and Future Developments.International journal of molecular sciences · 2025
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 2 countries.

Christopher B RodellFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Madonna E LeeFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Hua WangFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Satoshi TakebayashiFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Tetsushi TakayamaFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Tomonori KawamuraFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Jeffrey S ArklesFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Neville N DusajFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Shauna M DorseyFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Walter R T WitscheyFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
James J PillaFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Joseph H GormanFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Jonathan F WenkFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington.
Jason A BurdickFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington. burdick2@seas.upenn.edu Robert.Gorman@uphs.upenn.edu.
Robert C GormanFrom the Department of Bioengineering (C.B.R., N.N.D., S.M.D., J.A.B.), Gorman Cardiovascular Research Group, Department of Surgery (M.E.L., S.T., T.T., T.K., J.S.A., J.H.G., R.C.G.), and Department of Radiology (W.R.T.W., J.J.P.), University of Pennsylvania, Philadelphia; and Department of Mechanical Engineering (H.W., J.F.W.) and Department of Surgery (J.F.W.), University of Kentucky, Lexington. burdick2@seas.upenn.edu Robert.Gorman@uphs.upenn.edu.
University of Kentucky · US

Funding

Surgery to Prevent Post Infarction Ventricular RemodelingR01HL063954 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GORMAN, ROBERT C · 2001 to 2018
$9.8M
Localized Targeting of Matrix Proteases Following Myocardial InfarctionR01HL111090 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BURDICK, JASON A, SPINALE, FRANCIS G · 2012 to 2015
$2.0M
NHLBI NIH HHS R01 HL063954NHLBI NIH HHS R01 HL111090
6 · The paper itself

Abstract

backgroundInjectable, acellular biomaterials hold promise to limit left ventricular remodeling and heart failure precipitated by infarction through bulking or stiffening the infarct region. A material with tunable properties (eg, mechanics, degradation) that can be delivered percutaneously has not yet been demonstrated. Catheter-deliverable soft hydrogels with in vivo stiffening to enhance therapeutic efficacy achieve these requirements. METHODS AND

resultsWe developed a hyaluronic acid hydrogel that uses a tandem crosslinking approach, where the first crosslinking (guest-host) enabled injection and localized retention of a soft (<1 kPa) hydrogel. A second crosslinking reaction (dual-crosslinking) stiffened the hydrogel (41.4±4.3 kPa) after injection. Posterolateral infarcts were investigated in an ovine model (n≥6 per group), with injection of saline (myocardial infarction control), guest-host hydrogels, or dual-crosslinking hydrogels. Computational (day 1), histological (1 day, 8 weeks), morphological, and functional (0, 2, and 8 weeks) outcomes were evaluated. Finite-element modeling projected myofiber stress reduction (>50%; P<0.001) with dual-crosslinking but not guest-host injection. Remodeling, assessed by infarct thickness and left ventricular volume, was mitigated by hydrogel treatment. Ejection fraction was improved, relative to myocardial infarction at 8 weeks, with dual-crosslinking (37% improvement; P=0.014) and guest-host (15% improvement; P=0.058) treatments. Percutaneous delivery via endocardial injection was investigated with fluoroscopic and echocardiographic guidance, with delivery visualized by magnetic resonance imaging.

conclusionsA percutaneous delivered hydrogel system was developed, and hydrogels with increased stiffness were found to be most effective in ameliorating left ventricular remodeling and preserving function. Ultimately, engineered systems such as these have the potential to provide effective clinical options to limit remodeling in patients after infarction.

Indexed as

Biocompatible MaterialsAnimalsBiomechanical PhenomenaBiopsyCross-Linking ReagentsDisease Models, AnimalEchocardiographyFinite Element AnalysisHyaluronic AcidHydrogelsInjectionsMagnetic Resonance ImagingMaleModels, CardiovascularMyocardial InfarctionMyocardiumBiocompatible MaterialsCross-Linking ReagentsHyaluronic AcidHydrogelsheart failurehydrogelmyocardial infarctionpercutaneous treatmentremodeling

Identifiers

PMID27729419
PMCPMC5123705
OpenAlexW2531286452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.