ArticleCarcinogenesis2016
Integration of a radiation biomarker into modeling of thyroid carcinogenesis and post-Chernobyl risk assessment.
Article in Carcinogenesis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Somatic health effects of Chernobyl: 30 years on.European journal of epidemiology · 2017Pooled it
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- Radiation-Related Thyroid Cancer.Endocrine reviews · 2024Review
- Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure toScientific reports · 2022Article
- Comprehensive analysis for detecting radiation-specific molecules expressed during radiation-induced rat thyroid carcinogenesis.Journal of radiation research · 2021Article
- Adverse outcome pathways, key events, and radiation risk assessment.International journal of radiation biology · 2021Review
- Utility of gene expression studies in relation to radiation exposure and clinical outcomes: thyroid cancer in the Ukrainian-American cohort and late health effects in a MAYAK worker cohort.International journal of radiation biology · 2021Review
- Transcriptome network of the papillary thyroid carcinoma radiation marker CLIP2.Radiation oncology (London, England) · 2020Article
- Organ-Specific Effects of Low Dose Radiation Exposure: A Comprehensive Review.Frontiers in genetics · 2020Review
- Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure.PloS one · 2020Article
- Doses of Ukrainian female clean-up workers with diagnosed breast cancer.Radiation and environmental biophysics · 2018Article
- Lessons from Fukushima: Latest Findings of Thyroid Cancer After the Fukushima Nuclear Power Plant Accident.Thyroid : official journal of the American Thyroid Association · 2018Article
- Thyroid Cancer Incidence around the Belgian Nuclear Sites, 2000-2014.International journal of environmental research and public health · 2017Article
- Radiation and Thyroid Cancer.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strong evidence for the statistical association between radiation exposure and disease has been produced for thyroid cancer by epidemiological studies after the Chernobyl accident. However, limitations of the epidemiological approach in order to explore health risks especially at low doses of radiation appear obvious. Statistical fluctuations due to small case numbers dominate the uncertainty of risk estimates. Molecular radiation markers have been searched extensively to separate radiation-induced cancer cases from sporadic cases. The overexpression of the CLIP2 gene is the most promising of these markers. It was found in the majority of papillary thyroid cancers (PTCs) from young patients included in the Chernobyl tissue bank. Motivated by the CLIP2 findings we propose a mechanistic model which describes PTC development as a sequence of rate-limiting events in two distinct paths of CLIP2-associated and multistage carcinogenesis. It integrates molecular measurements of the dichotomous CLIP2 marker from 141 patients into the epidemiological risk analysis for about 13 000 subjects from the Ukrainian-American cohort which were exposed below age 19 years and were put under enhanced medical surveillance since 1998. For the first time, a radiation risk has been estimated solely from marker measurements. Cross checking with epidemiological estimates and model validation suggests that CLIP2 is a marker of high precision. CLIP2 leaves an imprint in the epidemiological incidence data which is typical for a driver gene. With the mechanistic model, we explore the impact of radiation on the molecular landscape of PTC. The model constitutes a unique interface between molecular biology and radiation epidemiology.
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