ArticleBlood2016
Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis.
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In one paragraph
Article in Blood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 169 citations in OpenAlex.
- Trial
- Trial
- Novel activating BRAF fusion identifies a recurrent alternative mechanism for ERK activation in pediatric Langerhans cell histiocytosis.Pediatric blood & cancer · 2018Trial
- Langerhans cell histiocytosis: molecular mechanisms underlying pathogenesis and emerging targeted therapeutics.Cancer metastasis reviews · 2026Review
- Identification of Metabolic Biomarkers in Bone Marrow Aspirate for Diagnosis, Prognosis, and Therapeutic Monitoring in Pediatric Langerhans Cell Histiocytosis.Annals of laboratory medicine · 2026Article
- Pathogenic myeloid phenotypes drive disease pathology in a novel human neurohistiocytosis model.Blood · 2026Article
- Pre-diagnostic metabolites in peripheral blood of Langerhans cell histiocytosis children with posterior pituitary involvement.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Origin, diagnosis and treatment of periocular Histiocytic disorders- state-of-the-art review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real-world study.International journal of cancer · 2026Article
- Histiocytoses and reactive proliferations of histiocytes: current state of the art and evolving concepts-a report from the joint CSHP-EA4HP-SH workshop 2024, Hefei, China.Virchows Archiv : an international journal of pathology · 2026Review
- RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition.Cancer cell · 2026Article
- Isolated gastric Langerhans cell histiocytosis: a case report and literature review.Frontiers in oncology · 2026Article
- Advances in the diagnosis and management of pediatric Langerhans cell histiocytosis and Rosai-Dorfman disease: therapies, biomarkers, and response assessment.Hematology. American Society of Hematology. Education Program · 2025Review
- [Langerhans cell histiocytosis diagnosed in mediastinal lymph nodes by endoscopic ultrasound-guided fine-needle aspiration].Anales del sistema sanitario de Navarra · 2025Article
- Histiocyte Society blueprint for non-Langerhans cell histiocytosis research: unraveling complex diseases through collaboration.Haematologica · 2025Review
- Article
- Unraveling the Genetic Landscape of Langerhans Cell Histiocytosis in Korean Patients: Comprehensive Insights from Mutational Profiles and Clinical Correlations.Cancer research and treatment · 2025Article
- A case of diagnosis and treatment of mediastinal Langerhans cytosis.Journal of cardiothoracic surgery · 2025Article
- Circulating monocytes decrease significantly following disease-directed therapy and may reflect disease expansion in Langerhans Cell Histiocytosis.Annals of hematology · 2024Article
- Beyond BRAFCancer medicine · 2024Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 3 countries.
Rikhia ChakrabortyTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Thomas M BurkeTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Oliver A HamptonDepartment of Molecular and Human Genetics.
Daniel J ZinnTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Karen Phaik Har LimTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Harshal AbhyankarTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Brooks ScullTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Vijetha KumarDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX; and.
Nipun KakkarDepartment of Molecular and Human Genetics.
David A WheelerDepartment of Molecular and Human Genetics.
Angshumoy RoyDivision of Pediatric Hematology-Oncology, Department of Pediatrics.
Poulikos I PoulikakosTisch Cancer Institute, Icahn School of Medicine, New York, NY.
Miriam MeradTisch Cancer Institute, Icahn School of Medicine, New York, NY.
Kenneth L McClainTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
D Williams ParsonsTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Carl E AllenTexas Children's Cancer Center, Texas Children's Hospital, Houston, TX.
Children's Cancer Center · USTexas Children's Hospital · USTisch Hospital · USBaylor College of Medicine · USPediatric Oncology Group · CA
Funding
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MTissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, HELEN E HESLOP · 2007 to 2026
$51.4MHematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3MERK control of Dendritic Cell Differentiation, Homeostasis and DiseaseR01CA154947 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARL E ALLEN, MIRIAM MERAD · 2011 to 2026
$7.0MContribution of the cutaneous APC network to melanoma progression and therapy.R01CA173861 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2013 to 2017
$2.1MHarnessing Csf-2 compartmentalized role on tissue resident phagocytes to uncouple anti-tumoral from pathological immunity induced by checkpoint inhibitorsR01CA190400 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2015 to 2019
$1.9MRedefining Langerhans Cell Histiocytosis as a Myeloid Dysplasia and Identifying BR01CA154489 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ALLEN, CARL E · 2011 to 2015
$1.6MHoward Hughes Medical InstituteNCI NIH HHS P30 CA125123NCI NIH HHS P50 CA126752NCI NIH HHS R01 CA154489NCI NIH HHS R01 CA154947NCI NIH HHS R01 CA173861NCI NIH HHS R01 CA190400NHGRI NIH HHS U54 HG003273NIDDK NIH HHS T32 DK060445
Abstract
Langerhans cell histiocytosis (LCH) is characterized by inflammatory lesions containing pathologic CD207
Indexed as
MutationAdolescentAdultAgedChildChild, PreschoolEnzyme ActivationFemaleHistiocytosis, Langerhans-CellHumansInfantMaleOncogene Proteins, FusionProtein DomainsProto-Oncogene Proteins B-rafBRAF protein, humanOncogene Proteins, FusionProto-Oncogene Proteins B-raf
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.