High fructose-mediated attenuation of insulin receptor signaling does not affect PDGF-induced proliferative signaling in vascular smooth muscle cells.

Islam Osman, Ninu Poulose, Vadivel Ganapathy, Lakshman Segar

Abstract read

In one paragraph

Article in European journal of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

1.0field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.Current hypertension reports · 2022
Review
SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation.BMC cardiovascular disorders · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Islam OsmanCenter for Pharmacy and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, USA; Charlie Norwood VA Medical Center, Augusta, GA, USA.

Ninu PouloseCenter for Pharmacy and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, USA; Charlie Norwood VA Medical Center, Augusta, GA, USA.

Vadivel GanapathyDepartment of Biochemistry and Molecular Biology, Augusta University, Augusta, GA, USA.

Lakshman SegarCenter for Pharmacy and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, USA; Charlie Norwood VA Medical Center, Augusta, GA, USA; Vascular Biology Center, Department of Pharmacology and Toxicology, Augusta University, Augusta, GA, USA; Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA. Electronic address: lsegar@augusta.edu.

Augusta University · USCharlie Norwood VA Medical Center · USUniversity of Georgia · US

Funding

Vascular Phenotypic Regulation by Growth Factors, Insulin and GlucoseR01HL097090 · NHLBI · UNIVERSITY OF GEORGIA · PI SEGAR, LAKSHMAN · 2010 to 2015

$1.4M

NHLBI NIH HHS R01 HL097090

6 · The paper itself

Abstract

Insulin resistance is associated with accelerated atherosclerosis. Although high fructose is known to induce insulin resistance, it remains unclear as to how fructose regulates insulin receptor signaling and proliferative phenotype in vascular smooth muscle cells (VSMCs), which play a major role in atherosclerosis. Using human aortic VSMCs, we investigated the effects of high fructose treatment on insulin receptor substrate-1 (IRS-1) serine phosphorylation, insulin versus platelet-derived growth factor (PDGF)-induced phosphorylation of Akt, S6 ribosomal protein, and extracellular signal-regulated kinase (ERK), and cell cycle proteins. In comparison with PDGF (a potent mitogen), neither fructose nor insulin enhanced VSMC proliferation and cyclin D1 expression. d-[

Indexed as

AortaCell ProliferationCyclin D1Cyclin-Dependent Kinase Inhibitor p27Dose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesFructoseGene Expression RegulationHumansInsulin Receptor Substrate ProteinsMuscle, Smooth, VascularPhosphorylationPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, InsulinRibosomal Protein S6Cyclin D1Cyclin-Dependent Kinase Inhibitor p27Extracellular Signal-Regulated MAP KinasesFructoseInsulin Receptor Substrate ProteinsIRS1 protein, humanIRS2 protein, humanPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, InsulinRibosomal Protein S6SerineFructoseInsulinInsulin receptor substratePDGFProliferationVascular smooth muscle cells

Identifiers

PMID27729247

DOI10.1016/j.ejphar.2016.10.007

PMCPMC5107134

OpenAlexW2531682656

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.