ArticleChinese journal of cancer2016
Radiation-induced osteosarcoma of the maxilla and mandible after radiotherapy for nasopharyngeal carcinoma.
Article in Chinese journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinicopathologic Analysis of Sarcomas in the Oral and Maxillofacial Region: A Systematic Review.Oral diseases · 2026Pooled it
- Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review.Advances in therapy · 2021Pooled it
- Case Report on Radiation-Induced Osteosarcoma of the Nasopharynx: Unmasking the Aftermath.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- [Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution retrospective study].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Radiation-Induced Oropharyngeal Squamous Cell Carcinoma: Case Report and Review of the Literature.Current oncology (Toronto, Ont.) · 2023Review
- Prognostic factors and treatment outcomes of spinal osteosarcoma: Surveillance, epidemiology, and end results database analysis.Frontiers in oncology · 2023Article
- Radiation-induced intracranial osteosarcoma of the anterior skull base after treatment of esthesioneuroblastoma.BMJ case reports · 2021Article
- A nomogram for predicting cancer-specific survival in patients with osteosarcoma as secondary malignancy.Scientific reports · 2020Article
- Suspected Radiation-Induced Osteosarcoma in a Domestic Shorthair Cat.Case reports in veterinary medicine · 2020Article
- Predictors of the Survival of Primary and Secondary Older Osteosarcoma Patients.Journal of Cancer · 2019Article
- Osteosarcoma of the jaw - experience at the Medical University Vienna and comparative study with international tumor registries.Clinics (Sao Paulo, Brazil) · 2019Article
- Knockdown of Annexin A1 Enhances Radioresistance and Inhibits Apoptosis in Nasopharyngeal Carcinoma.Technology in cancer research & treatment · 2018Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing incidence of radiation-induced osteosarcoma of the maxilla and mandible (RIOSM) has become a significant problem that can limit long-term survival. The purpose of this study was to analyze the association of clinicopathologic characteristics with treatment outcomes and prognostic factors of patients who developed RIOSM after undergoing radiotherapy for nasopharyngeal carcinoma (NPC).
methodsWe reviewed the medical records of 53,760 NPC patients admitted to Sun Yat-sen University Cancer Center during the period August 1964 to August 2012. Of these patients, 47 who developed RISOM and met inclusion criteria were included in this study. Two of these 47 patients refused treatment and were then excluded.
resultsFor all patients treated for NPC at Sun Yat-sen University Cancer Center during the study period, the total incidence of RIOSM after radiotherapy was 0.084% (47/53,760). Two patients (4.4%) had metastases at the diagnosis of RIOSM. Thirty-nine of the 45 (86.7%) patients underwent surgery for RIOSM; most patients (24/39; 61.5%) who underwent resection had gross clear margins, with 15 patients (38.5%) having either a gross or microscopic positive margin. All patients died. The 1-, 2-, and 3-year overall survival (OS) rates for the entire cohort of 45 patients were 53.3%, 35.6% and 13.5%, respectively. The independent prognostic factors associated with high OS rate were tumor size and treatment type.
conclusionsRISOM after radiotherapy for NPC is aggressive and often eludes early detection and timely intervention. Surgery combined with postoperative chemotherapy might be an effective treatment to improve patient survival.
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