ArticleMolecular brain2016
Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits.
Article in Molecular brain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Stress-induced GHS-R1a expression in medial prefrontal cortical neurons promotes vulnerability to anxiety in mice.Communications biology · 2025Article
- Microglial depletion rescues spatial memory impairment caused by LPS administration in adult mice.PeerJ · 2024Article
- Synaptic plasticity in schizophrenia pathophysiology.IBRO neuroscience reports · 2023Article
- A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation.Experimental animals · 2023Article
- Synaptic plasticity in schizophrenia pathophysiology.IBRO neuroscience reports · 2022Article
- Ghrelin infusion into the basolateral amygdala suppresses CTA memory formation in rats via the PI3K/Akt/mTOR and PLC/PKC signaling pathways.Acta pharmacologica Sinica · 2022Article
- Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats.Neurobiology of stress · 2022Article
- Peculiarities of the Composition of Peripheral Immune Cells and Cytokine Profile in Brain Structures in Mutant DISC1-L100P Mice.Bulletin of experimental biology and medicine · 2021Article
- Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia.Molecular psychiatry · 2021Article
- Inherited L1 Retrotransposon Insertions Associated With Risk for Schizophrenia and Bipolar Disorder.Schizophrenia bulletin open · 2021Article
- Conditional Dnmt3b deletion in hippocampal dCA1 impairs recognition memory.Molecular brain · 2020Article
- Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington's disease treatment.Scientific reports · 2019Article
- GHS-R1a Deficiency Alleviates Depression-Related Behaviors After Chronic Social Defeat Stress.Frontiers in neuroscience · 2019Article
- Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms.Scientific reports · 2018Article
- Mechanisms underlying the role of DISC1 in synaptic plasticity.The Journal of physiology · 2018Review
- Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington's disease.Molecular brain · 2018Article
- Overexpression ofFrontiers in cellular neuroscience · 2018Article
- Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease.Frontiers in cellular neuroscience · 2018Article
- Adolescent Isolation Interacts WithFrontiers in cellular neuroscience · 2018Article
- Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors.Molecular brain · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disrupted-in-schizophrenia 1(DISC1) is a promising candidate susceptibility gene for a spectrum of psychiatric illnesses that share cognitive impairments in common, including schizophrenia, bipolar disorder and major depression. Here we report that DISC1 L100P homozygous mutant shows normal anxiety- and depression-like behavior, but impaired object recognition which is prevented by administration of atypical antipsychotic drug clozapine. Ca
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