Evidence map›Paper›PMID 27729073›Full record

Trial reportArthritis research & therapy2016

Efficacy of glucosamine plus diacerein versus monotherapy of glucosamine: a double-blind, parallel randomized clinical trial.

Jatupon Kongtharvonskul, Patarawan Woratanarat, Mark McEvoy, John Attia, Siwadol Wongsak, Viroj Kawinwonggowit, Ammarin Thakkinstian

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01906801 (Clinical Efficacy of Glucosamine Plus Diacerein Versus Mono-therapy of Glucosamine), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01906801 phase4completednot on this map

Clinical Efficacy of Glucosamine Plus Diacerein Versus Mono-therapy of Glucosamine

TypeinterventionalSponsorRamathibodi HospitalRan2013 to 2014Enrolled148ConditionsOsteoarthritis, Glucosamine, DiacereinArmsGlucosamine sulfate, Diacerein, Placebo (for Diacerein)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jatupon KongtharvonskulSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. jatupon_kong@hotmail.com.
Patarawan WoratanaratDepartment of Orthopedics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Mark McEvoyCentre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, NSW, Australia.
John AttiaCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Siwadol WongsakDepartment of Orthopedics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Viroj KawinwonggowitDepartment of Orthopedics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Ammarin ThakkinstianSection for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Mahidol University · THRamathibodi Hospital · THHunter Medical Research Institute · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatented crystalline glucosamine sulfate (pCGS) and diacerein monotherapy have been recommended for treatment of mild to moderate osteoarthritis (OA), but evidence of efficacy for combined treatments is lacking. Therefore, the aim of this study was to compare clinical outcomes (i.e., pain and Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] score) at 6 months as well as the safety profile of treatment with combined pCGS and diacerein versus pCGS alone.

methodsA double-blind, parallel randomized controlled superiority trial was conducted between August 2013 and August 2014 at Ramathibodi Hospital, Bangkok, Thailand. A total of 148 patients (74 patients in each group) was randomly allocated to receive pCGS plus diacerein or pCGS plus placebo daily. Adult patients with OA were eligible if they had a Kellgren-Lawrence grade of 2-3. The primary outcomes were visual analogue scale score (VAS) for pain and WOMAC subscores measured at 24 weeks after receiving treatment, using the intention-to-treat principle (nonresponder imputation).

resultsAmong the 148 patients in the study, mean age and body mass index were 60 years and 28.1 kg/m

conclusionsThis study did not demonstrate that coadministration of diacerein with pCGS improves pain and WOMAC score compared with pCGS monotherapy in patients with mild to moderate OA of the knee.

trial registrationClinicalTrials.gov identifier: NCT01906801 . Registered on 20 July 2013.

Indexed as

AdultAgedAnthraquinonesAnti-Inflammatory AgentsDouble-Blind MethodDrug Therapy, CombinationFemaleGlucosamineHumansMaleMiddle AgedOsteoarthritis, KneePain MeasurementTreatment OutcomeAnthraquinonesAnti-Inflammatory AgentsdiacereinGlucosamineCombined therapyDiacereinGlucosamineKneeMonotherapyOsteoarthritis

Identifiers

PMID27729073
PMCPMC5059980
OpenAlexW2531261174

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.