ArticleCurrent biology : CB2016
Gene Regulation: Activation through Space.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Complex small-world regulatory networks emerge from the 3D organisation of the human genome.Nature communications · 2021Article
- The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.Nature communications · 2021Article
- Antagonism betweeneLife · 2021Article
- DNA Double-Strand Breaks Are a Critical Regulator of Fear Memory Reconsolidation.International journal of molecular sciences · 2020Article
- Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations.Nucleic acids research · 2018Review
- Eukaryotic core promoters and the functional basis of transcription initiation.Nature reviews. Molecular cell biology · 2018Review
- A high-throughput method to identify trans-activation domains within transcription factor sequences.The EMBO journal · 2018Article
- Article
- Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.Genes & development · 2018Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent study visualizes nascent RNAs in live Drosophila embryos to establish a connection between enhancer strength and the frequency of transcriptional bursts. Interestingly, one enhancer can simultaneously activate two core promoters, challenging models of enhancer-core-promoter communication via direct protein-protein contacts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.