Evidence map›Paper›PMID 27727484›Full record

ArticleCancer science2016

Comparison of tumor-infiltrating lymphocytes between primary and metastatic tumors in breast cancer patients.

Rin Ogiya, Naoki Niikura, Nobue Kumaki, Giampaolo Bianchini, Shigehisa Kitano, Takayuki Iwamoto, Naoki Hayashi, Kozue Yokoyama, Risa Oshitanai, Mayako Terao and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Trial
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  6. The CD94/NKG2A-HLA-E Axis as a Target in Cancer Immunotherapy: A Critical Perspective.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
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  8. Article
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  14. Observational
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  19. Cancer of unknown primary derived from regressed breast cancer.Journal of cancer research and clinical oncology · 2024
    Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Rin OgiyaDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Naoki NiikuraDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Nobue KumakiDepartment of Pathology, School of Medicine, Tokai University, Isehara, Japan.
Giampaolo BianchiniDepartment of Medical Oncology, Ospedale San Raffaele, Milan, Italy.
Shigehisa KitanoDepartment of Experimental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital, Tokyo, Japan.
Takayuki IwamotoDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Naoki HayashiDepartment of Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan.
Kozue YokoyamaDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Risa OshitanaiDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Mayako TeraoDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Toru MoriokaDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Banri TsudaDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Takuho OkamuraDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Yuki SaitoDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Yasuhiro SuzukiDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Yutaka TokudaDepartment of Breast and Endocrine Surgery, School of Medicine, Tokai University, Isehara, Japan.
Tokai University · JPIRCCS Ospedale San Raffaele · ITOkayama University Hospital · JPSt. Luke's International Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of tumor-infiltrating lymphocytes (TILs) is associated with favorable long-term outcome in breast cancer. However, little is known about changes in TILs during metastatic progression. To confirm our hypothesis that malignant tumors escape from the host immune system during metastasis, we evaluated the percentage of TILs in paired samples of primary and metastatic breast tumors. We retrospectively identified 25 patients with human epidermal growth factor receptor-2 (HER2

Indexed as

AdultBiomarkersBiopsyBreast NeoplasmsFemaleHumansImmunohistochemistryImmunophenotypingLymphocyte CountLymphocytes, Tumor-InfiltratingLymphocyte SubsetsMiddle AgedNeoplasm GradingNeoplasm MetastasisNeoplasm StagingBiomarkersImmune microenvironmentimmunohistochemistrymetastatic breast tumorprimary breast tumortumor-infiltrating lymphocytes

Identifiers

PMID27727484
PMCPMC5198965
OpenAlexW2531056238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.