ArticleTranslational psychiatry2016
Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Protein aggregation identified in olfactory neuronal cells is associated with cognitive impairments in a subset of living schizophrenia patients.Molecular psychiatry · 2025Article
- Disorder-specific neurodynamic features in schizophrenia inferred by neurodynamic embedded contrastive variational autoencoder model.Translational psychiatry · 2024Article
- Human olfactory neural progenitor cells reveal differences in IL-6, IL-8, thrombospondin-1, and MCP-1 in major depression disorder and borderline personality disorder.Frontiers in psychiatry · 2024Article
- Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology.International journal of molecular sciences · 2023Article
- Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology.bioRxiv : the preprint server for biology · 2023Article
- Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?Translational psychiatry · 2022Review
- Sex-specific involvement of the Notch-JAG pathway in social recognition.Translational psychiatry · 2022Article
- Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in the Periphery of Patients with Schizophrenia.Journal of molecular neuroscience : MN · 2022Article
- Long non-coding RNA-associated competing endogenous RNA axes in the olfactory epithelium in schizophrenia: a bioinformatics analysis.Scientific reports · 2021Article
- Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia.Scientific reports · 2021Article
- Making Sense of Patient-Derived iPSCs, Transdifferentiated Neurons, Olfactory Neuronal Cells, and Cerebral Organoids as Models for Psychiatric Disorders.The international journal of neuropsychopharmacology · 2021Review
- Molecular signature of extracellular matrix pathology in schizophrenia.The European journal of neuroscience · 2021Article
- Construction and Analysis of a Diagnostic Model Based on Differential Expression Genes in Patients With Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Widespread transcriptional disruption of the microRNA biogenesis machinery in brain and peripheral tissues of individuals with schizophrenia.Translational psychiatry · 2020Article
- Central and Peripheral Changes in FOS Expression in Schizophrenia Based on Genome-Wide Gene Expression.Frontiers in genetics · 2019Article
- Olfactory deficits in individuals at risk for psychosis and patients with schizophrenia: relationship with socio-cognitive functions and symptom severity.European archives of psychiatry and clinical neuroscience · 2018Article
- Olfactory Functioning in First-Episode Psychosis.Schizophrenia bulletin · 2018Article
- Disrupted Olfactory Integration in Schizophrenia: Functional Connectivity Study.The international journal of neuropsychopharmacology · 2017Article
- Application of olfactory tissue and its neural progenitors to schizophrenia and psychiatric research.Current opinion in psychiatry · 2017Review
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
Abstract
Cognitive impairment is a key feature of schizophrenia (SZ) and determines functional outcome. Nonetheless, molecular signatures in neuronal tissues that associate with deficits are not well understood. We conducted nasal biopsy to obtain olfactory epithelium from patients with SZ and control subjects. The neural layers from the biopsied epithelium were enriched by laser-captured microdissection. We then performed an unbiased microarray expression study and implemented a systematic neuropsychological assessment on the same participants. The differentially regulated genes in SZ were further filtered based on correlation with neuropsychological traits. This strategy identified the SMAD 5 gene, and real-time quantitative PCR analysis also supports downregulation of the SMAD pathway in SZ. The SMAD pathway has been important in multiple tissues, including the role for neurodevelopment and bone formation. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD pathway may be a novel target in addressing cognitive deficit of SZ in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.