Evidence map›Paper›PMID 27727172›Full record

ArticleSensors (Basel, Switzerland)2016

Low-Coherence Reflectometry for Refractive Index Measurements of Cells in Micro-Capillaries.

Francesca Carpignano, Giulia Rigamonti, Giuliano Mazzini, Sabina Merlo

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Francesca CarpignanoDipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia, Via Ferrata 5, I-27100 Pavia, Italy. carpignano@unipv.it.
Giulia RigamontiDipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia, Via Ferrata 5, I-27100 Pavia, Italy. giulia.rigamonti01@universitadiapavia.it.
Giuliano MazziniIstituto di Genetica Molecolare IGM-C.N.R., Via Abbiategrasso 207, I-27100 Pavia, Italy. mazzi@igm.cnr.it.
Sabina MerloDipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia, Via Ferrata 5, I-27100 Pavia, Italy. sabina.merlo@unipv.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The refractive index of cells provides insights into their composition, organization and function. Moreover, a good knowledge of the cell refractive index would allow an improvement of optical cytometric and diagnostic systems. Although interferometric techniques undoubtedly represent a good solution for quantifying optical path variation, obtaining the refractive index of a population of cells non-invasively remains challenging because of the variability in the geometrical thickness of the sample. In this paper, we demonstrate the use of infrared low-coherence reflectometry for non-invasively quantifying the average refractive index of cell populations gently confined in rectangular glass micro-capillaries. A suspension of human red blood cells in plasma is tested as a reference. As a use example, we apply this technique to estimate the average refractive index of cell populations belonging to epithelial and hematological families.

Indexed as

CapillariesCells, CulturedEquipment DesignHumansInterferometryRefractometrycell culturescell refractive indexdrug discoveryinfrared radiationlow-coherence reflectometryrectangular micro-capillary

Identifiers

PMID27727172
PMCPMC5087458

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.