ReviewTrends in parasitology2017
Mathematical Modelling to Guide Drug Development for Malaria Elimination.
Review in Trends in parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis.The Journal of infectious diseases · 2022Pooled it
- Pooled it
- Trial
- Molecular mechanisms underlying drug resistance in protozoan parasites: emerging mechanisms and therapeutic perspectives.Frontiers in parasitology · 2026Review
- Triple artemisinin-based combination therapy (TACT): advancing malaria control and eradication efforts.Malaria journal · 2024Review
- Article
- Expert perspectives on the introduction of Triple Artemisinin-based Combination Therapies (TACTs) in Southeast Asia: a Delphi study.BMC public health · 2022Article
- Challenges for modelling interventions for future pandemics.Epidemics · 2022Article
- Operational research: A multidisciplinary approach for the management of infectious disease in a global context.European journal of operational research · 2021Article
- Researchers' perceptions of malaria eradication: findings from a mixed-methods analysis of a large online survey.Malaria journal · 2020Article
- Early transmission of sensitive strain slows down emergence of drug resistance in Plasmodium vivax.PLoS computational biology · 2020Article
- The role of windows of selection and windows of dominance in the evolution of insecticide resistance in human disease vectors.Evolutionary applications · 2020Article
- Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development.Scientific reports · 2020Article
- How delayed and non-adherent treatment contribute to onward transmission of malaria: a modelling study.BMJ global health · 2019Article
- An ecosystem framework for understanding and treating disease.Evolution, medicine, and public health · 2018Review
- Reply to Rossi et al.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Mathematical models of the dynamics of a drug within the host are now frequently used to guide drug development. These generally focus on assessing the efficacy and duration of response to guide patient therapy. Increasingly, antimalarial drugs are used at the population level, to clear infections, provide chemoprevention, and to reduce onward transmission of infection. However, there is less clarity on the extent to which different drug properties are important for these different uses. In addition, the emergence of drug resistance poses new threats to longer-term use and highlights the need for rational drug development. Here, we argue that integrating within-host pharmacokinetic and pharmacodynamic (PK/PD) models with mathematical models for the population-level transmission of malaria is key to guiding optimal drug design to aid malaria elimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.