Evidence map›Paper›PMID 27726947›Full record

ArticleThe Journal of allergy and clinical immunology2017

Vitamin D over the first decade and susceptibility to childhood allergy and asthma.

Elysia M Hollams, Shu Mei Teo, Merci Kusel, Barbara J Holt, Kathryn E Holt, Michael Inouye, Nicholas H De Klerk, Guicheng Zhang, Peter D Sly, Prue H Hart and 1 more

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In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Article
  10. Vitamin D and allergic diseases.Frontiers in immunology · 2024
    Review
  11. Article
  12. The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Vitamin D, skin filaggrin, allergic sensitization, and race.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Article
  17. Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Elysia M HollamsTelethon Kids Institute, University of Western Australia, Perth, Australia.
Shu Mei TeoCentre for Systems Genomics, University of Melbourne, Melbourne, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Australia; School of BioSciences, University of Melbourne, Melbourne, Australia.
Merci KuselTelethon Kids Institute, University of Western Australia, Perth, Australia.
Barbara J HoltTelethon Kids Institute, University of Western Australia, Perth, Australia.
Kathryn E HoltCentre for Systems Genomics, University of Melbourne, Melbourne, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Australia.
Michael InouyeCentre for Systems Genomics, University of Melbourne, Melbourne, Australia; School of BioSciences, University of Melbourne, Melbourne, Australia.
Nicholas H De KlerkTelethon Kids Institute, University of Western Australia, Perth, Australia.
Guicheng ZhangSchool of Public Health, Curtin University, Perth, Australia.
Peter D SlyUniversity of Queensland, Brisbane, Australia.
Prue H HartTelethon Kids Institute, University of Western Australia, Perth, Australia.
Patrick G HoltTelethon Kids Institute, University of Western Australia, Perth, Australia; University of Queensland, Brisbane, Australia. Electronic address: Patrick.Holt@telethonkids.org.au.
The Kids Research Institute Australia · AUThe University of Melbourne · AUThe University of Queensland · AUCurtin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D (25(OH)D) deficiency has been implicated as a possible risk factor for asthma development, but studies at selected time points measuring 25(OH)D levels during childhood have yielded conflicting findings. Prospective studies tracking 25(OH)D levels during the initiation phase of asthma in early childhood have not been reported.

objectiveWe sought to elucidate relationships between 25(OH)D levels from birth to age 10 years and susceptibility to allergic sensitization, respiratory tract infections, and asthma.

methodsAsthma-, allergy-, and respiratory tract infection-associated phenotypes (including pathogen identification) were characterized in a high-risk birth cohort. Plasma 25(OH)D concentrations were quantified at birth and at clinical follow-ups at the ages of 0.5, 1, 2, 3, 4, 5, and 10 years, and relationships with clinical outcomes were examined.

resultsCross-sectional analyses demonstrated inverse associations between 25(OH)D concentrations and the risk for concurrent sensitization at age 0.5, 2, and 3 years, and mixed-effects regression demonstrated inverse longitudinal associations of 25(OH)D levels with both sensitization and eczema. Multivariate regression modeling suggested that the number of 25(OH)D-deficient follow-ups was positively associated with risk for asthma/wheeze, eczema, and sensitization at 10 years; adjustment for sensitization (particularly by 2 years) in the asthma/wheeze models reduced 25(OH)D associations with these latter outcomes. 25(OH)D levels were also inversely associated with early nasopharyngeal colonization with Streptococcus species and age of first febrile lower respiratory illness, both of which are known asthma risk factors.

conclusion25(OH)D deficiency in early childhood is associated with increased risk for persistent asthma, potentially through modulating susceptibility to early allergic sensitization, upper respiratory tract colonization with bacterial pathogens, or both. These relationships are only evident if 25(OH)D status is monitored prospectively and longitudinally.

Indexed as

Disease SusceptibilityImmunizationAsthmaChildChild, PreschoolCohort StudiesCross-Sectional StudiesFemaleFollow-Up StudiesHumansHypersensitivityImmunoglobulin EInfantInfant, NewbornMaleProspective StudiesImmunoglobulin EVitamin Dallergyasthmachildhoodlongitudinal birth cohortmicrobiomerespiratory infectionsStreptococcusVitamin D

Identifiers

PMID27726947
OpenAlexW2528302074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.