Evidence map›Paper›PMID 27726420›Full record

ArticleDNA and cell biology2016

Mitochondrial Ribosomal Protein L10 Associates with Cyclin B1/Cdk1 Activity and Mitochondrial Function.

Hai-Bo Li, Ruo-Xi Wang, Hai-Bo Jiang, En-Dong Zhang, Jie-Qiong Tan, Hui-Zhuo Xu, Rong-Rong Zhou, Xiao-Bo Xia

Open access · hybridAbstract read
In one paragraph

Article in DNA and cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins.International journal of molecular sciences · 2021
    Review
  12. Review
  13. Article
  14. MaizePlant physiology · 2019
    Article
  15. Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated GChinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hai-Bo Li1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
Ruo-Xi Wang2 The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University , Changsha, China .
Hai-Bo Jiang1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
En-Dong Zhang1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
Jie-Qiong Tan2 The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University , Changsha, China .
Hui-Zhuo Xu1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
Rong-Rong Zhou3 Department of Oncology, Xiangya Hospital, Central South University , Changsha, China .
Xiao-Bo Xia1 Department of Ophthalmology, Xiangya Hospital, Central South University , Changsha, China .
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial ribosomal proteins are important for mitochondrial-encoded protein synthesis and mitochondrial function. In addition to their roles in mitoribosome assembly, several mitochondrial ribosome proteins are also implicated in cellular processes like cell cycle regulation, apoptosis, and mitochondrial homeostasis regulation. Here, we demonstrate that MRPL10 regulates cyclin B1/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein synthesis in mammalian cells. In Drosophila, inactivation of mRpL10 (the Drosophila ortholog of mammalian MRPL10) in eyes results in abnormal eye development. Furthermore, expression of human cyclin B1 suppresses eye phenotypes and mitochondrial abnormality of mRpL10 knockdown Drosophila. This study identified that the physiological regulatory pathway of MRPL10 and providing new insights into the role of MRPL10 in growth control and mitochondrial function.

Indexed as

ApoptosisCDC2 Protein KinaseCells, CulturedCyclin B1Cyclin-Dependent KinasesHumansMitochondriaMitochondrial ProteinsPhosphorylationRibosomal Protein L10Ribosomal ProteinsCDC2 Protein KinaseCDK1 protein, humanCyclin B1Cyclin-Dependent KinasesMitochondrial ProteinsRibosomal ProteinsRPL10 protein, humancyclin B1Drp1mitochondrial fissionMRPL10

Identifiers

PMID27726420
PMCPMC5105351
OpenAlexW2533449524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.