Evidence map›Paper›PMID 27726301›Full record

ArticleCancer medicine2016

Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans.

Sang-Yong Eom, Seon-Mi Hong, Dong-Hyuk Yim, Hyo-Jin Kwon, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, Sei-Jin Youn, Taisun Hyun, Joo-Seung Park and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Sang-Yong EomDepartment of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Seon-Mi HongDepartment of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Dong-Hyuk YimDepartment of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Hyo-Jin KwonDepartment of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Dae-Hoon KimDepartment of Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea.
Hyo-Yung YunDepartment of Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea.
Young-Jin SongDepartment of Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea.
Sei-Jin YounDepartment of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.
Taisun HyunDepartment of Food and Nutrition, Chungbuk National University, Cheongju, Korea.
Joo-Seung ParkDepartment of Surgery, College of Medicine, Eulji University, Daejon, Korea.
Byung Sik KimDepartment of Surgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea.
Yong-Dae KimDepartment of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Heon KimDepartment of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Chungbuk National University · KREulji University · KRUniversity of Ulsan · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although several studies reported genetic polymorphisms in protein kinase AMP-activated alpha 1 catalytic subunit (PRKAA1) and their associations with gastric cancer risk, few have evaluated associations between Helicobacter pylori infection and PRKAA1 gene-environment interactions. Here, we evaluated the effects of interactions between H. pylori infection and PRKAA1 polymorphisms on gastric cancer risk in Koreans. In this hospital-based case-control study, PRKAA1 genotypes were analyzed and H. pylori infection and CagA status were examined using a serologic method in 846 pairs of gastric cancer patients and controls matched for age and sex. H. pylori seropositivity was associated with a 1.43-fold [95% confidence interval: 1.12-1.81] increase in the risk of gastric cancer, and CagA low-positive titers during H. pylori infection increased the risk by 1.85-fold (95% confidence interval, 1.38-2.48). Significant positive interaction between the PRKAA1 rs13361707 genotype and H. pylori infection was verified on an additive scale [relative excess risk due to interaction, 0.55; 95% confidence interval, 0.05-1.04; P = 0.030], and the gene-environment interaction between PRKAA1 rs13361707 and CagA status was also statistically significant (relative excess risk due to interaction, 0.50; 95% confidence interval, 0.30-0.70; P < 0.001). Our results indicated that H. pylori infection, CagA status, and PRKAA1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk.

Indexed as

Helicobacter pyloriPolymorphism, GeneticAgedAMP-Activated Protein KinasesCase-Control StudiesFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenotypeHelicobacter InfectionsHumansMaleOdds RatioRepublic of KoreaRisk FactorsStomach NeoplasmsAMP-Activated Protein KinasesPRKAA1 protein, humanAMP-activated protein kinasegastric cancergene-environment interactionHelicobacter pylori

Identifiers

PMID27726301
PMCPMC5119980
OpenAlexW2531029239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.