ArticleHuman brain mapping2017
In-vivo measurements of human brain tissue conductivity using focal electrical current injection through intracerebral multicontact electrodes.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
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- Variation in Reported Human Head Tissue Electrical Conductivity Values.Brain topography · 2019Pooled it
- ECoG high-gamma modulation versus electrical stimulation for presurgical language mapping.Epilepsy & behavior : E&B · 2018Pooled it
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- Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.Brain : a journal of neurology · 2025Article
- Temperature and Frequency Dependence of Human Cerebrospinal Fluid Dielectric Parameters.Sensors (Basel, Switzerland) · 2024Article
- Variability of cortico-cortical evoked potentials in the epileptogenic zone is related to seizure occurrence.Annals of clinical and translational neurology · 2024Article
- Brain Wearables: Validation Toolkit for Ear-Level EEG Sensors.Sensors (Basel, Switzerland) · 2024Article
- Multifunctional Fiber-Based Optoacoustic Emitter as a Bidirectional Brain Interface.Advanced healthcare materials · 2023Article
- Impedance Rhythms in Human Limbic System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Remote targeted electrical stimulation.Journal of neural engineering · 2023Article
- Comparing electrical stimulation functional mapping with subdural electrodes and stereoelectroencephalography.Epilepsia · 2023Article
- Validating EEG source imaging using intracranial electrical stimulation.Brain communications · 2023Article
- Parasitic Effects on Electrical Bioimpedance Systems: Critical Review.Sensors (Basel, Switzerland) · 2022Review
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- Neurophysiological considerations for visual implants.Brain structure & function · 2022Review
- Novel Electrode Placement in Electrical Bioimpedance-Based Stroke Detection: Effects on Current Penetration and Injury Characterization in a Finite Element Model.IEEE transactions on bio-medical engineering · 2022Article
- Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In-vivo measurements of human brain tissue conductivity at body temperature were conducted using focal electrical currents injected through intracerebral multicontact electrodes. A total of 1,421 measurements in 15 epileptic patients (age: 28 ± 10) using a radiofrequency generator (50 kHz current injection) were analyzed. Each contact pair was classified as being from healthy (gray matter, n = 696; white matter, n = 530) or pathological (epileptogenic zone, n = 195) tissue using neuroimaging analysis of the local tissue environment and intracerebral EEG recordings. Brain tissue conductivities were obtained using numerical simulations based on conductivity estimates that accounted for the current flow in the local brain volume around the contact pairs (a cube with a side length of 13 mm). Conductivity values were 0.26 S/m for gray matter and 0.17 S/m for white matter. Healthy gray and white matter had statistically different median impedances (P < 0.0001). White matter conductivity was found to be homogeneous as normality tests did not find evidence of multiple subgroups. Gray matter had lower conductivity in healthy tissue than in the epileptogenic zone (0.26 vs. 0.29 S/m; P = 0.012), even when the epileptogenic zone was not visible in the magnetic resonance image (MRI) (P = 0.005). The present in-vivo conductivity values could serve to create more accurate volume conduction models and could help to refine the identification of relevant intracerebral contacts, especially when located within the epileptogenic zone of an MRI-invisible lesion. Hum Brain Mapp 38:974-986, 2017. © 2016 Wiley Periodicals, Inc.
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