ArticleHuman brain mapping2017
Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic-clonic seizure.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers.
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Who cites it
200 citing papers in PubMed, 351 citations in OpenAlex.
- Trial
- Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures.The journal of headache and pain · 2018Trial
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- Independent component analysis of brain network alterations associated with cognitive impairment in coal workers' pneumoconiosis.BMC medical imaging · 2026Article
- Altered Brain Dynamics in Heavy Smokers Revealed by Dynamic Functional Network Connectivity Analysis.Brain topography · 2026Article
- Dynamic Analysis of Gray Matter and White Matter Functional Network Connectivity in Individuals with Temporal Lobe Epilepsy.Research square · 2026Article
- Altered Dynamic Functional Network Connectivity in Post-Stroke Aphasia.Annals of clinical and translational neurology · 2026Article
- Network flexibility facilitates treatment-induced recovery in post-stroke aphasia.Brain communications · 2026Article
- Alterations in subgenual anterior cingulate cortex functional connectivity underlie depressive symptoms in chronic insomnia disorder.Frontiers in psychiatry · 2026Article
- Article
- Altered dynamic functional connectivity associated with cognition in diverse severity of white matter hyperintensity.BMC medical imaging · 2025Article
- A Study on dynamic functional connectivity and efficacy prediction of SAINT for rapid antidepressant effects and relief of suicidal ideation.Translational psychiatry · 2025Article
- Comprehensive review of machine learning and deep learning techniques for epileptic seizure detection and prediction based on neuroimaging modalities.Visual computing for industry, biomedicine, and art · 2025Review
- Effective Connectivity Alterations of Directed Brain Network in Pediatric Patients With Spinal Cord Injury.CNS neuroscience & therapeutics · 2025Article
- Alterations of multilayer network correlated with cognitive impairment and gene expression profiles in children with idiopathic generalized epilepsy.Scientific reports · 2025Article
- Functional connectivity and graph theory of impaired central visual pathways in acute ischemic stroke based on functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Olfactory identification impairment in cerebral small-vessel disease indicates cognitive network disconnection and predicts accelerated cognitive decline.Journal of neurology · 2025Article
- Motor and default mode network states of rest in frontal lobe epilepsy.Neuroimage. Reports · 2025Article
- Early detection of cognitive impairment in end-stage renal disease patients undergoing hemodialysis: insights from Resting-State functional connectivity analysis.BMC nephrology · 2025Article
140 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic generalized epilepsy (IGE) has been linked with disrupted intra-network connectivity of multiple resting-state networks (RSNs); however, whether impairment is present in inter-network interactions between RSNs, remains largely unclear. Here, 50 patients with IGE characterized by generalized tonic-clonic seizures (GTCS) and 50 demographically matched healthy controls underwent resting-state fMRI scans. A dynamic method was implemented to investigate functional network connectivity (FNC) in patients with IGE-GTCS. Specifically, independent component analysis was first carried out to extract RSNs, and then sliding window correlation approach was employed to obtain dynamic FNC patterns. Finally, k-mean clustering was performed to characterize six discrete functional connectivity states, and state analysis was conducted to explore the potential alterations in FNC and other dynamic metrics. Our results revealed that state-specific FNC disruptions were observed in IGE-GTCS and the majority of aberrant functional connectivity manifested itself in default mode network. In addition, temporal metrics derived from state transition vectors were altered in patients including the total number of transitions across states and the mean dwell time, the fraction of time spent and the number of subjects in specific FNC state. Furthermore, the alterations were significantly correlated with disease duration and seizure frequency. It was also found that dynamic FNC could distinguish patients with IGE-GTCS from controls with an accuracy of 77.91% (P < 0.001). Taken together, this study not only provided novel insights into the pathophysiological mechanisms of IGE-GTCS but also suggested that the dynamic FNC analysis was a promising avenue to deepen our understanding of this disease. Hum Brain Mapp 38:957-973, 2017. © 2016 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.