ArticleThe Laryngoscope2017
Otoconia and otolithic membrane fragments within the posterior semicircular canal in benign paroxysmal positional vertigo.
Article in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Association between otolin-1 and benign paroxysmal positional vertigo: A meta-analysis.Frontiers in neurology · 2022Pooled it
- Difference in the immediate effect on positional nystagmus for head positions with interval time during Epley maneuver: a randomized trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Trial
- Reuniting and Endolymphatic Duct Macrophages: Localization and Possible Roles.Audiology research · 2025Article
- Exploring the Link Between Traumatic Brain Injury and Benign Paroxysmal Positional Vertigo.Cureus · 2025Review
- Epley's Influence on Horizontal Canal BPPV Variants.Audiology research · 2025Review
- A review of Meniere's disease - reflection of published MRI, ECochG and newer otoconial theory from Aotearoa New Zealand.Journal of the Royal Society of New Zealand · 2025Article
- Impact of head orientation and head movement in traditional manual diagnostics of benign paroxysmal positional vertigo: a randomized controlled crossover study.Frontiers in neurology · 2025Article
- Seasonality in benign paroxysmal positional vertigo: a systematic review.BMJ neurology open · 2025Article
- Benign paroxysmal positional vertigo: A case report in which four wrongs made a right.Clinical case reports · 2024Article
- Increased prevalence of peripheral vestibular disorder among patients with Fabry disease.Orphanet journal of rare diseases · 2024Article
- Benign paroxysmal positional vertigo and asymmetric hearing loss: is the worst hearing ear likely to suffer from otoconial displacement?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Intelligent analysis and measurement of semicircular canal spatial attitude.Frontiers in neurology · 2024Article
- Neurological update: neuro-otology 2023.Journal of neurology · 2023Article
- Diagnostic Positional Tests and Therapeutic Maneuvers in the Management of Benign Paroxysmal Positional Vertigo.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Evaluation of retrootolithic function using galvanic vestibular-evoked myogenic potentials in patients with benign paroxysmal positional vertigo.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Immediate repeated testing (IRT) for BPPV: A cost-effective examination.Laryngoscope investigative otolaryngology · 2022Article
- Vestibular Test Results in Patients With Horizontal Canal Benign Paroxysmal Positional Vertigo.Cureus · 2022Article
- Canal switch in benign paroxysmal positional vertigo: Clinical characteristics and possible mechanisms.Frontiers in neurology · 2022Article
- Advances in otolith-related protein research.Frontiers in neuroscience · 2022Review
- Benign Paroxysmal Positional Vertigo: Is It Really an Otolith Disease?The journal of international advanced otology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectives/hypothesisBenign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder with an incidence between 10.7 and 17.3 per 100,000 persons per year. The mechanism for BPPV has been postulated to involve displaced otoconia resulting in canalithiasis. Although particulate matter has been observed in the endolymph of affected patients undergoing posterior canal occlusion surgery, an otoconial origin for the disease is still questioned. STUDY
designIn this study, particulate matter was extracted from the posterior semicircular canal of two patients and examined with scanning electron microscopy.
methodsThe samples were obtained from two patients intraoperatively during posterior semicircular canal occlusion. The particles were fixed, stored in ethanol, and chemically dehydrated. The samples were sputter coated and viewed under a scanning electron microscope. Digital images were obtained.
resultsIntact and degenerating otoconia with and without linking filaments were found attached to amorphous particulate matter. Many otoconia appeared to be partially embedded in a gel matrix, presumably that which encases and anchors the otoconia within the otolith membrane, whereas others stood alone with no attached filaments and matrix. The otoconia measured roughly 2 to 8 μm in length and displayed a uniform outer shape with a cylindrical bulbous body and a 3 + 3 rhombohedral plane at each end.
conclusionsThese findings suggest that the source of the particulate matter in the semicircular canals of patients with BPPV is broken off fragments of the utricular otolithic membrane with attached and detached otoconia. LEVEL OF EVIDENCE: NA Laryngoscope, 127:709-714, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.