SynthesisCurrent environmental health reports2016
The Relation Between Low-Level Lead Exposure and Oxidative Stress: a Review of the Epidemiological Evidence in Children and Non-Occupationally Exposed Adults.
Synthesis in Current environmental health reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Association Between Low-Level Lead Exposure and Serum Gamma-Glutamyl Transferase Concentrations as a Biomarker of Oxidative Stress in U.S. Adolescents Aged 12-19 Years.International journal of environmental research and public health · 2025Article
- Oxidative Stress in Children and Adolescents: Insights Into Human Biology.American journal of human biology : the official journal of the Human Biology Council · 2025Review
- Heavy metal pollution and ischemic stroke: multimechanistic pathogenesis and countermeasures.Frontiers in public health · 2025Review
- Athelia rolfsii Exopolysaccharide Protection Against Kidney Injury in Lead-Exposed Mice via Nrf2 Signaling Pathway.Biological trace element research · 2023Article
- Low-level exposure to lead, mercury, arsenic, and cadmium, and blood pressure among 8-17-year-old participants of the 2009-2016 National Health and Nutrition Examination Survey.Environmental research · 2021Article
- Mangiferin exerts neuroprotective activity against lead-induced toxicity and oxidative stress via Nrf2 pathway.Chinese herbal medicines · 2020Article
- Exploring telomere length in mother-newborn pairs in relation to exposure to multiple toxic metals and potential modifying effects by nutritional factors.BMC medicine · 2019Article
- Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children.Environmental research · 2018Article
- Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental studies in animals and observational studies in occupationally exposed adults indicate that higher lead exposure results in higher biomarkers of oxidative stress. However, this evidence cannot be extended to the general population who typically experience lower levels of lead exposure. This systematic review evaluates the epidemiological evidence on the association between lead and oxidative stress in non-occupationally exposed general population, with a particular focus on the pediatric population. Studies were identified through a systematic search of Medline and Web of Science. Ultimately, evidence from 15 studies conducted in children and 22 studies in adults from the general population was reviewed. Overall, the published findings are inconsistent, and there are very few well-designed studies on the relation between lead exposure and oxidative stress in the general population. The strength of the current evidence is discussed in light of the methodological approaches employed, and recommendations are made for future research directions. These include designing prospective studies with repeat measurements of clinically relevant oxidative stress markers to answer the question of causality and sensitive windows and reanalyzing previously published data, but using multivariable statistical approaches and adjustment for relevant explanatory factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.