Evidence map›Paper›PMID 27726067›Full record

SynthesisCurrent psychiatry reports2016

Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments.

Fleur Harrison, Liesbeth Aerts, Henry Brodaty

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current psychiatry reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pharmacological interventions for apathy in Alzheimer's disease.The Cochrane database of systematic reviews · 2018
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The Effect of Agomelatine in Behavioral and Psychological Symptoms of Dementia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
    Article
  10. Article
  11. Article
  12. The Experience of Apathy in Dementia: A Qualitative Study.International journal of environmental research and public health · 2021
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Apathy Mediates Cognitive Difficulties in Geriatric Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fleur HarrisonDementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, University of New South Wales Australia, Sydney, NSW, 2052, Australia.
Liesbeth AertsDementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, University of New South Wales Australia, Sydney, NSW, 2052, Australia.
Henry BrodatyDementia Collaborative Research Centre-Assessment and Better Care, School of Psychiatry, University of New South Wales Australia, Sydney, NSW, 2052, Australia. h.brodaty@unsw.edu.au.
Dementia Collaborative Research Centres · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing recognition that apathy is one of the most prevalent behavioral and psychological symptoms of dementia and causes substantial caregiver distress has led to trials evaluating psychosocial and pharmacological treatments of apathy in dementia. We evaluated evidence of the efficacy of pharmacotherapies for apathy in dementia from studies since 2013. Previously reported benefits of acetylcholinesterase inhibitors and memantine were not replicated in recent studies. Antidepressants had mixed results with positive effects for apathy shown only for agomelatine, while stimulants, analgesics, and oxytocin study results were inconclusive. For some approaches, such as antipsychotic review, positive effects were found only in combination with nonpharmacological approaches. Relatively few studies assessed apathy outcomes specifically, complicating interpretation of potentially positive treatment effects; none dissected outcomes for emotional, motivational and behavioral components of apathy. Better trial design and more detailed analysis are needed in order to evaluate outcomes of pharmacological treatments for apathy.

Indexed as

Antidepressive AgentsAntipsychotic AgentsApathyCentral Nervous System StimulantsCholinesterase InhibitorsDementiaDopamine AgentsHumansMemantineAntidepressive AgentsAntipsychotic AgentsCentral Nervous System StimulantsCholinesterase InhibitorsDopamine AgentsMemantineAlzheimer’s diseaseApathyBPSDDementiaNeuropsychiatric symptomsPharmacotherapy

Identifiers

PMID27726067
OpenAlexW2530173846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.