ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Added clinical use of trabecular bone score to BMD for major osteoporotic fracture prediction in older Chinese people: the Mr. OS and Ms. OS cohort study in Hong Kong.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- Single-component imaging and ultrasound-based tools for the assessment of fracture risk.Nature reviews. Rheumatology · 2026Review
- Wubi Shanyao Pills ameliorate glucocorticoid-induced osteoporosis by regulating bone marrow T cell homing as an immune intermediate to restore bone metabolism.Chinese medicine · 2026Article
- The development and validation of a prediction model for imminent vertebral osteoporotic fracture in postmenopausal women.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The Added Value of Trabecular Bone Score in Evaluating Fracture Risk Among Polish Women Aged 40-76 Years.Journal of clinical medicine · 2026Article
- For older women, the majority of hip fragility fractures and radiographic vertebral fragility fractures occur among the densitometrically osteoporotic population: a literature analysis.Quantitative imaging in medicine and surgery · 2024Review
- Fracture risk prediction in old Chinese people-a narrative review.Archives of osteoporosis · 2023Review
- Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective.Aging and disease · 2023Article
- Fracture risk gradient assessed by categories of bone mineral density and trabecular bone score: the Manitoba BMD Registry.Archives of osteoporosis · 2023Article
- Comparison of Trabecular Bone Score-Adjusted Fracture Risk Assessment (TBS-FRAX) and FRAX Tools for Identification of High Fracture Risk among Taiwanese Adults Aged 50 to 90 Years with or without Prediabetes and Diabetes.Medicina (Kaunas, Lithuania) · 2022Article
- Estimations of bone mineral density defined osteoporosis prevalence and cutpoint T-score for defining osteoporosis among older Chinese population: a framework based on relative fragility fracture risks.Quantitative imaging in medicine and surgery · 2022Article
- Prediction Models for Osteoporotic Fractures Risk: A Systematic Review and Critical Appraisal.Aging and disease · 2022Review
- RELATIONSHIP BETWEEN TBS SCORE, BONE DENSITY AND FRACTURES IN OLDER MEN: INTEGRATIVE REVIEW.Acta ortopedica brasileira · 2022Article
- Association of short sleep duration and trabecular bone score.Scientific reports · 2021Article
- Changes in trabecular bone score and bone mineral density in Chinese HIV-Infected individuals after one year of antiretroviral therapy.Journal of orthopaedic translation · 2021Article
- Application of the Trabecular Bone Score in Clinical Practice.Journal of bone metabolism · 2021Article
- Article
- Cumulative and Incremental Value of Sarcopenia Components on Predicting Adverse Outcomes.Journal of the American Medical Directors Association · 2020Article
- Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- Cost-effectiveness of osteoporosis screening strategies for hip fracture prevention in older Chinese people: a decision tree modeling study in the Mr. OS and Ms. OS cohort in Hong Kong.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thresholds of trabecular bone score (TBS) require validation for clinical application in older Chinese people. The lower threshold of TBS significantly improved the accuracy of prediction by bone mineral density-based osteoporosis status for major osteoporotic fracture in older Chinese men.
introductionTrabecular bone score (TBS) is a relatively new indicator of skeletal fragility. Its clinical application warrants further investigations. Our aim was to validate and recommend practical thresholds of TBS for fracture prediction in older Chinese people.
methodsOlder men and women in Mr. and Ms. Os (Hong Kong) study were followed up for an average of 9.94 ± 2.77 and 8.82 ± 1.49 years, respectively. Major osteoporotic fracture (MOF) risks of TBS category in each BMD category (normal, osteopenia, or osteoporosis) were compared using Poisson regression model. The improved fracture risk prediction power was evaluated by the sensitivity, the specificity, the area under the receiver-operating characteristic curve (AUC), and the net reclassification improvement index (NRI).
resultsMOF incidence gradually increased with the increased risk categories of bone mineral density (BMD) and tertiles of TBS both in men and women. Compared with the lowest risk category, the rate ratios (RR, 95 % CI) of MOF for osteoporosis with the lowest TBS was 9.66 (4.19-22.26) and 6.24 (1.53-25.42) in men and women, respectively. The fracture risk for osteopenic men with the lowest TBS was significantly higher than that for normal men, with RR (95 % CI) of 4.68 (2.11-10.41). The predictive power of osteoporosis alone was significantly improved by TBS in men [mean AUC (95 % CI) rose from 0.604 (0.562-0.646) to 0.666 (0.623-0.710) and sensitivity rose from 32.5 to 64.3 %]. The improvement in predictive power was not significant in older women.
conclusionsTBS in combination with BMD can predict MOF more reliably in older men than by BMD alone.
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