ArticleNeurophotonics2017
Correlation between volumetric oxygenation responses and electrophysiology identifies deep thalamocortical activity during epileptic seizures.
Article in Neurophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations.Epilepsia · 2024Review
- Simultaneous Functional Magnetic Resonance and Optoacoustic Imaging of Brain-Wide Sensory Responses in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice.Nature biomedical engineering · 2022Article
- Challenges and Perspectives of Mapping Locus Coeruleus Activity in the Rodent with High-Resolution fMRI.Brain sciences · 2022Article
- Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain-Wide Sensory Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Practical review on photoacoustic computed tomography using curved ultrasound array transducer.Biomedical engineering letters · 2022Review
- Multi-scale optoacoustic molecular imaging of brain diseases.European journal of nuclear medicine and molecular imaging · 2021Review
- Emerging imaging methods to study whole-brain function in rodent models.Translational psychiatry · 2021Review
- 3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic computed tomography.Quantitative imaging in medicine and surgery · 2021Article
- Spherical Array System for High-Precision Transcranial Ultrasound Stimulation and Optoacoustic Imaging in Rodents.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Application of Optogenetics in Epilepsy Research.Advances in experimental medicine and biology · 2021Article
- A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases-Actual Applications and Future Perspectives.Diagnostics (Basel, Switzerland) · 2020Review
- Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.Journal of neural engineering · 2020Article
- Monitoring of Stimulus Evoked Murine Somatosensory Cortex Hemodynamic Activity With Volumetric Multi-Spectral Optoacoustic Tomography.Frontiers in neuroscience · 2020Article
- High-Throughput Platform for Optoacoustic Probing of Genetically Encoded Calcium Ion Indicators.iScience · 2019Article
- Listening to tissues with new light: recent technological advances in photoacoustic imaging.Journal of optics (2010) · 2019Article
- Optical-resolution photoacoustic microscopy of oxygen saturation with nonlinear compensation.Biomedical optics express · 2019Article
- Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain.Nature biomedical engineering · 2019Article
- Spatial and Spectral Mapping and Decomposition of Neural Dynamics and Organization of the Mouse Brain with Multispectral Optoacoustic Tomography.Cell reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Visualization of whole brain activity during epileptic seizures is essential for both fundamental research into the disease mechanisms and the development of efficient treatment strategies. It has been previously discussed that pathological synchronization originating from cortical areas may reinforce backpropagating signaling from the thalamic neurons, leading to massive seizures through enhancement of high frequency neural activity in the thalamocortical loop. However, the study of deep brain neural activity is challenging with the existing functional neuroimaging methods due to lack of adequate spatiotemporal resolution or otherwise insufficient penetration into subcortical areas. To investigate the role of thalamocortical activity during epileptic seizures, we developed a new functional neuroimaging framework based on spatiotemporal correlation of volumetric optoacoustic hemodynamic responses with the concurrent electroencephalogram recordings and anatomical brain landmarks. The method is shown to be capable of accurate three-dimensional mapping of the onset, spread, and termination of the epileptiform events in a 4-aminopyridine acute model of focal epilepsy. Our study is the first to demonstrate entirely noninvasive real-time visualization of synchronized epileptic foci in the whole mouse brain, including the neocortex and subcortical structures, thus opening new vistas in systematic studies toward the understanding of brain signaling and the origins of neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.