Evidence map›Paper›PMID 27725930›Full record

ArticleFrontiers in medicine2016

Combination of Antiretroviral Drugs and Radioimmunotherapy Specifically Kills Infected Cells from HIV-Infected Individuals.

Dina Tsukrov, Alicia McFarren, Alfred Morgenstern, Frank Bruchertseifer, Eugene Dolce, Miroslaw K Gorny, Susan Zolla-Pazner, Joan W Berman, Ellie Schoenbaum, Barry S Zingman and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Recent Advancements in Radiopharmaceuticals for Infection Imaging.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  2. Review
  3. Potential Use of Radiolabeled Antibodies for Imaging and Treatment of COVID-19.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  4. Review
  5. Future Vistas in Alpha Therapy of Infectious Diseases.Journal of medical imaging and radiation sciences · 2019
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Dina TsukrovAlbert Einstein College of Medicine , Bronx, NY , USA.
Alicia McFarrenAlbert Einstein College of Medicine , Bronx, NY , USA.
Alfred MorgensternEuropean Commission, Joint Research Centre, Institute for Transuranium Elements , Karlsruhe , Germany.
Frank BruchertseiferEuropean Commission, Joint Research Centre, Institute for Transuranium Elements , Karlsruhe , Germany.
Eugene DolceAlbert Einstein College of Medicine , Bronx, NY , USA.
Miroslaw K GornyNew York University School of Medicine , New York, NY , USA.
Susan Zolla-PaznerNew York University School of Medicine, New York, NY, USA; Veterans Affairs New York Harbor Healthcare System, New York, NY, USA.
Joan W BermanAlbert Einstein College of Medicine , Bronx, NY , USA.
Ellie SchoenbaumAlbert Einstein College of Medicine , Bronx, NY , USA.
Barry S ZingmanAlbert Einstein College of Medicine , Bronx, NY , USA.
Arturo CasadevallAlbert Einstein College of Medicine , Bronx, NY , USA.
Ekaterina DadachovaAlbert Einstein College of Medicine , Bronx, NY , USA.
Albert Einstein College of Medicine · USJoint Research Centre · DENew York University · US

Funding

Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Mechanisms of HAD:Role of CCL2 BBB & HIV InfectionR01MH075679 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERMAN, JOAN WEINBERGER · 2006 to 2016
$4.0M
Clinical and Translational Science AwardTL1TR001072 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHAMOON, HARRY · 2013 to 2017
$909k
NCATS NIH HHS TL1 TR001072NCATS NIH HHS UL1 TR001073NIMH NIH HHS R01 MH075679
6 · The paper itself

Abstract

Eliminating virally infected cells is an essential component of any HIV eradication strategy. Radioimmunotherapy (RIT), a clinically established method for killing cells using radiolabeled antibodies, was recently applied to target HIV-1 gp41 antigen expressed on the surface of infected cells. Since gp41 expression by infected cells is likely downregulated in patients on antiretroviral therapy (ART), we evaluated the ability of RIT to kill ART-treated infected cells using both

Indexed as

antiretroviral therapybismuth-213gp41HIVpatientsradioimmunotherapy

Identifiers

PMID27725930
PMCPMC5035742
OpenAlexW2521347292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.