Evidence map›Paper›PMID 27725887›Full record

Trial reportNeural plasticity2016

Training-Specific Neural Plasticity in Spinal Reflexes after Incomplete Spinal Cord Injury.

Atif S Khan, Susan K Patrick, Francois D Roy, Monica A Gorassini, Jaynie F Yang

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01765153 (Precision Versus Endurance Training to Improve Walking After Chronic Incomplete SCI), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01765153 nacompletednot on this map

Precision Versus Endurance Training to Improve Walking After Chronic Incomplete SCI

TypeinterventionalSponsorUniversity of AlbertaRan2008 to 2012Enrolled21ConditionsSpinal Cord InjuryArmsEndurance, Precision
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Brain Plasticity in Patients with Spinal Cord Injuries: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Descending Brainstem Systems Contribute to Ankle Clonus in Humans with Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Atif S KhanNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0003-0253-4439
Susan K PatrickFaculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Francois D RoyNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Monica A GorassiniNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada; Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.
Jaynie F YangNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada; Department of Physical Therapy, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-7507-8924
University of Alberta · CA

Funding

CIHR
6 · The paper itself

Abstract

The neural plasticity of spinal reflexes after two contrasting forms of walking training was determined in individuals with chronic, motor-incomplete spinal cord injury (SCI). Endurance Training involved treadmill walking for as long as possible, and Precision Training involved walking precisely over obstacles and onto targets overground. Twenty participants started either Endurance or Precision Training for 2 months and then crossed over after a 2-month rest period to the other form of training for 2 months. Measures were taken before and after each phase of training and rest. The cutaneomuscular reflex (CMR) during walking was evoked in the soleus (SOL) and tibialis anterior muscles by stimulating the posterior tibial nerve at the ankle. Clonus was estimated from the EMG power in the SOL during unperturbed walking. The inhibitory component of the SOL CMR was enhanced after Endurance but not Precision Training. Clonus did not change after either form of training. Participants with lower reflex excitability tended to be better walkers (i.e., faster walking speeds) prior to training, and the reduction in clonus was significantly correlated with the improvement in walking speed and distance. Thus, reflex excitability responded in a training-specific way, with the reduction in reflex excitability related to improvements in walking function. Trial registration number is NCT01765153.

Indexed as

AdultElectric StimulationElectromyographyExercise TestExercise TherapyFemaleHumansMaleMuscle, SkeletalNeuronal PlasticitySpinal Cord InjuriesWalking

Identifiers

PMID27725887
PMCPMC5048024
OpenAlexW2521202349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.