ArticleScientific reports2016
A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Next-generation antifungal peptide discovery: the synergy of artificial intelligence and omics technologies.World journal of microbiology & biotechnology · 2025Review
- Antimicrobial Peptides Act-6 and Act 8-20 Derived from Scarabaeidae Cecropins Exhibit Differential Antifungal Activity.Journal of fungi (Basel, Switzerland) · 2025Article
- Novel Arginine- and Proline-Rich Candidacidal Peptides Obtained through a Bioinformatic Approach.Antibiotics (Basel, Switzerland) · 2023Article
- Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase.ACS omega · 2023Article
- In Vitro Antifungal Activity of LL-37 Analogue Peptides againstJournal of fungi (Basel, Switzerland) · 2022Article
- In Silico Predicted Antifungal Peptides: In Vitro and In Vivo Anti-Journal of fungi (Basel, Switzerland) · 2021Article
- In Vitro and In Vivo Anti-Journal of fungi (Basel, Switzerland) · 2021Article
- Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi.Microorganisms · 2021Review
- A Peptide Found in Human Serum, Derived from the C-Terminus of Albumin, Shows Antifungal Activity In Vitro and In Vivo.Microorganisms · 2020Article
- In Vitro and In Vivo Inhibitory Activity of Limonene against Different Isolates ofJournal of fungi (Basel, Switzerland) · 2020Article
- Mechanisms of action of antimicrobial peptides ToAP2 and NDBP-5.7 against Candida albicans planktonic and biofilm cells.Scientific reports · 2020Article
- Fungicidal activity of peptides encoded by immunoglobulin genes.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.