Evidence map›Paper›PMID 27725724›Full record

ArticleScientific reports2016

Hepatocellular Carcinoma-propagating Cells are Detectable by Side Population Analysis and Possess an Expression Profile Reflective of a Primitive Origin.

Honghai Xia, Jun Cao, Qing Li, Yang Lv, Weidong Jia, Weihua Ren, Qingyu Cheng, Xiaoyuan Song, Geliang Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. NF-Y Overexpression in Liver Hepatocellular Carcinoma (HCC).International journal of molecular sciences · 2020
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Road to stemness in hepatocellular carcinoma.World journal of gastroenterology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Honghai XiaGraduate School, Tianjin Medical University, No. 22, Qixiangtai Road, Tianjin 300070, China.
Jun CaoCAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, No. 443, Huangshan Road, Hefei 230001, China.
Qing LiCentral Laboratory of Medical research center, Anhui Provincial Hospital, No. 17, Lujiang Road, Hefei 230001, China.
Yang LvAnhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Hospital, No. 17, Lujiang Road, Hefei 230001, China.
Weidong JiaAnhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Hospital, No. 17, Lujiang Road, Hefei 230001, China.
Weihua RenAnhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Hospital, No. 17, Lujiang Road, Hefei 230001, China.
Qingyu ChengCAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, No. 443, Huangshan Road, Hefei 230001, China.
Xiaoyuan SongCAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, No. 443, Huangshan Road, Hefei 230001, China.
Geliang XuGraduate School, Tianjin Medical University, No. 22, Qixiangtai Road, Tianjin 300070, China.
Anhui Provincial Hospital · CNUniversity of Science and Technology of China · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent identification of "Side Population" (SP) cells in a number of unrelated human cancers has renewed interests in the hypothesis of cancer stem cells. Here we isolated SP cells from HepG2 cells and 18 of the 21 fresh hepatocellular carcinoma (HCC) tissue samples. These SP cells have higher abilities of forming spheroids, invasion and migration. Tumors could generate only from SP, not non-SP (NSP), cells in a low dose of subcutaneous injection to the NOD/SCID mice (5 × 10

Indexed as

AnimalsCarcinoma, HepatocellularCCAAT-Binding FactorCell ProliferationGene Expression Regulation, NeoplasticHep G2 CellsHeterograftsHMGA2 ProteinHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsLiver NeoplasmsMiceMice, SCIDNeoplastic Stem CellsSide-Population CellsCCAAT-Binding FactorHMGA2 ProteinKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsNFYA protein, humanSALL4 protein, humanTranscription Factors

Identifiers

PMID27725724
PMCPMC5057076
OpenAlexW2531124853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.