ArticleScientific reports2016
The chitin synthase FgChs2 and other FgChss co-regulate vegetative development and virulence in F. graminearum.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Antifungal Potential ofJournal of fungi (Basel, Switzerland) · 2026Article
- Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025Review
- Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis.PLoS pathogens · 2025Article
- The Non-Histone Protein FgNhp6 Is Involved in the Regulation of the Development, DON Biosynthesis, and Virulence ofPathogens (Basel, Switzerland) · 2024Article
- Cell Wall Integrity Mediated by CfCHS1 Is Important for Growth, Stress Responses and Pathogenicity inJournal of fungi (Basel, Switzerland) · 2023Article
- Transcriptomic Profiling ofJournal of fungi (Basel, Switzerland) · 2023Article
- Palmitoyl Transferase FonPAT2-Catalyzed Palmitoylation of the FonAP-2 Complex Is Essential for Growth, Development, Stress Response, and Virulence in Fusarium oxysporum f. sp.Microbiology spectrum · 2023Article
- Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica.Molecular plant pathology · 2022Article
- Quantitative multiplexed proteomics analysis reveals reshaping of the lysine 2-hydroxyisobutyrylome in Fusarium graminearum by tebuconazole.BMC genomics · 2022Article
- Genomic footprints related with adaptation and fumonisins production inFrontiers in microbiology · 2022Article
- Genome-Wide Identification of bZIP Transcription Factor Genes and Functional Analyses of Two Members inJournal of fungi (Basel, Switzerland) · 2021Article
- Application of Double-Strand RNAs Targeting Chitin Synthase, Glucan Synthase, and Protein Kinase ReducesFrontiers in microbiology · 2021Article
- Article
- Secreted in Xylem Genes: Drivers of Host Adaptation inFrontiers in plant science · 2021Review
- Soil microbiota influences clubroot disease by modulating Plasmodiophora brassicae and Brassica napus transcriptomes.Microbial biotechnology · 2020Article
- Cell Wall Biogenesis Protein Phosphatase CrSsd1 Is Required for Conidiation, Cell Wall Integrity, and Mycoparasitism inFrontiers in microbiology · 2020Article
- Review
- The Myosin Motor Domain-Containing Chitin Synthases Are Involved in Cell Wall Integrity and Sensitivity to Antifungal Proteins inFrontiers in microbiology · 2019Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium graminearum contains eight chitin synthase (Chs) genes belonging to seven classes. Previous studies have found that deletion of FgChs3b is lethal to F. graminearum, and deletion of FgChs1, FgChs2, FgChs7 and FgChs5 caused diverse defects in chitin content, mycelial growth, conidiation, virulence or stress responses. However, little is known about the functional relationships among these FgChss. In this study, FgChs2 deletion mutant ΔFgChs2 exhibited reduced mycelial growth and virulence as reported previously. In addition, we found that the mutant produced thickened and "wavy" septa. Quantitative real-time PCR (qRT-PCR) assays showed that the expression levels of FgChs1, FgChs3a, FgChs4, FgChs7, FgChs5 and FgChs6 in ΔFgChs2 were significantly higher than those in the wild type. Therefore, we generated six double deletion mutants of FgChs2 and each of the above six FgChss, and found that FgChs2 shares a function with FgChs1 in regulating mycelial growth, and co-regulates conidiation with FgChs1, FgChs4, FgChs7 and FgChs5. Furthermore, FgChs2 and other six FgChss have overlapped functions in virulence, DON production and septum formation. Taken together, these results indicate that although each chitin synthase of F. graminearum plays certain roles, FgChss may co-regualte various cellular processes in F. graminearum.
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