ArticleNature communications2016
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 1 pooled it
19.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
228 citing papers in PubMed, 1 synthesis or guideline pooled it, 380 citations in OpenAlex.
- Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.Current diabetes reports · 2024Pooled it
- Sublingual NMN administration increases early circulating terminal catabolites 2PY and 4PY compared with oral administration in healthy adult men.Scientific reports · 2026Trial
- A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NADNutrients · 2022Trial
- Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.Journal of the International Society of Sports Nutrition · 2021Trial
- Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NADCell reports · 2019Trial
- Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults.Scientific reports · 2019Trial
- Integrated Multi-Omics Analyses Reveal the Effects of Different Diets on Growth, Digestion, and Intestinal Function in Megalobrama Pellegrini Larvae.Marine biotechnology (New York, N.Y.) · 2026Article
- Pyrroloquinoline Quinone and NADPharmaceuticals (Basel, Switzerland) · 2026Review
- NAMPT activation uncovers a senescence-specific vulnerability and promotes healthy aging in combination with NAM.bioRxiv : the preprint server for biology · 2026Article
- Nicotinic Acid Restriction Enhances the Therapeutic Benefit of NAMPT Inhibition in Small-Cell Lung Cancer Models.Cancer science · 2026Article
- Chemotherapy induces tissue NADbioRxiv : the preprint server for biology · 2026Article
- Amino-acids-mTORC1-driven DDA1 phosphorylation promotes DNA repair and glioblastoma progression.Cell communication and signaling : CCS · 2026Article
- Skin Cancer Prevention and Antiaging: Role of Nicotinamide.International journal of molecular sciences · 2026Review
- A Triple-Resonance NMR Strategy for the Selective Detection of NADSensors (Basel, Switzerland) · 2026Article
- A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex.Science (New York, N.Y.) · 2026Article
- Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis.Archives of toxicology · 2026Article
- Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice.Nature communications · 2026Article
- Niacin Derivatives in MASLD: Metabolic and Therapeutic Insights.Nutrients · 2026Review
- Reduced Versus Oxidized NADFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4Nature communications · 2026Article
168 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 4 countries.
Joanna RatajczakNestlé Institute of Health Sciences (NIHS), Lausanne CH-1015, Switzerland.
Magali JoffraudNestlé Institute of Health Sciences (NIHS), Lausanne CH-1015, Switzerland.
Samuel A J TrammellDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Rosa RasGroup of Research on Omic Methodologies (GROM), Universitat Rovira i Virgili, Reus 43204, Spain.
Núria CanelaGroup of Research on Omic Methodologies (GROM), Universitat Rovira i Virgili, Reus 43204, Spain.
Marie BoutantNestlé Institute of Health Sciences (NIHS), Lausanne CH-1015, Switzerland.
Sameer S KulkarniNestlé Institute of Health Sciences (NIHS), Lausanne CH-1015, Switzerland.
Marcelo RodriguesDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Philip RedpathSchool of Pharmacy, Queen's University Belfast, Belfast BT7 1NN, UK.
Marie E MigaudDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Johan AuwerxLaboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Oscar YanesCentre for Omic Sciences, Universitat Rovira i Virgili, Reus 43204, Spain.ORCID 0000-0003-3695-7157
Charles BrennerDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.ORCID 0000-0002-4955-3226
Carles CantóNestlé Institute of Health Sciences (NIHS), Lausanne CH-1015, Switzerland.ORCID 0000-0002-5167-7922
Institute for Work and Health · CHQueen's University Belfast · GBCentre for Omic Sciences · ESUniversity of Iowa · USCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESÉcole Polytechnique Fédérale de Lausanne · CH
Funding
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1MInsulin Resistance and Myocardial AutophagyR01HL108379 · NHLBI · UNIVERSITY OF UTAH · PI ABEL, E DALE · 2011 to 2014
$1.5MRole of Mitochondrial Protein Acetylation in the Liver Pathology of AlcoholR21AA022371 · NIAAA · UNIVERSITY OF IOWA · PI BRENNER, CHARLES M · 2014 to 2015
$372kNHLBI NIH HHS R01 HL108379NIAAA NIH HHS R21 AA022371NIGMS NIH HHS T32 GM008629
Abstract
NAD
Indexed as
AnimalsHepatocytesHep G2 CellsHumansInjections, IntraperitonealMammalsMice, KnockoutNADNiacinamideNicotinamide MononucleotidePhosphotransferases (Alcohol Group Acceptor)Pyridinium CompoundsNADNiacinamidenicotinamide-beta-ribosideNicotinamide MononucleotideNMRK1 protein, humanNmrk1 protein, mousePhosphotransferases (Alcohol Group Acceptor)Pyridinium Compounds
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.