ArticleNature communications2016
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome.
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Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.
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101citing papers in PubMed, 2 pooled it
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Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Research on potential biomarkers of prostate cancer in Latin America and the Caribbean: a scoping review.Frontiers in oncology · 2026Pooled it
- Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.Nature communications · 2019Pooled it
- Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial.Circulation. Genomic and precision medicine · 2022Trial
- Recovering the precolonial population structure of Khoe-San descendant populations.Science advances · 2026Article
- Cumulative genetic risk for asthma contributes to disease severity in children with asthma.The journal of allergy and clinical immunology. Global · 2026Article
- Mediation of coronary heart disease risk by genetic, socio-environmental, and lifestyle factors across racial groups.American journal of preventive cardiology · 2026Article
- Self-identified African ancestry and pathomics-derived tumor-infiltrating lymphocyte scores in colon and rectal adenocarcinoma whole-slide images: an exploratory multicohort whole-slide image study.Frontiers in oncology · 2026Article
- High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras.Genomics, proteomics & bioinformatics · 2025Review
- The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa.American journal of human genetics · 2025Article
- Genetic Variability in Child Growth Among South American Populations: A Perspective Integrating Population Genetics, Growth Standards, and Precision Growth Medicine.International journal of molecular sciences · 2025Review
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- Cumulative Genetic Risk for Asthma Contributes to Disease Severity in Children with Asthma living in Urban Environments.medRxiv : the preprint server for health sciences · 2025Article
- Uncovering genetic diversity and admixture of British Africans with HLA alleles inferred from whole genome sequencing.European journal of human genetics : EJHG · 2025Article
- The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CÓDIGO): building local capacity in genomics and bioinformatics.Communications biology · 2025Article
- Titin-Truncating variants predispose to dilated cardiomyopathy in populations genetically similar to african and european reference populations.PLoS genetics · 2025Article
- Universal Genetic Counseling and Testing for Black Women: A Risk-Stratified Approach to Addressing Breast Cancer Disparities.Clinical breast cancer · 2025Review
- Characterization of the phenotypic consequences of the Duffy-null genotype.Blood advances · 2025Article
- Multi-ancestry genome-wide association analyses: a comparison of meta- and mega-analyses in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study.BMC genomics · 2025Article
- The effect of African ancestry and mismatch-repair enzyme deficiency/microsatellite instability-high on colorectal adenocarcinoma immune gene expression.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Unveiling ancestral threads: Exploring CCR5 ∆32 mutation frequencies in Colombian populations for HIV/AIDS therapeutics.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
63 authors.
Rasika Ann MathiasDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Margaret A TaubDepartment of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA.
Christopher R GignouxDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Wenqing FuDepartment of Genomic Sciences, University of Washington, Seattle, Washington 98195, USA.
Shaila MusharoffDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Timothy D O'ConnorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Candelaria VergaraDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Dara G TorgersonDepartment of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
Maria Pino-YanesDepartment of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
Suyash S ShringarpureDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Lili HuangDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Nicholas RafaelsDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Meher Preethi BoorgulaDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Henry Richard JohnstonDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA.
Victor E OrtegaCenter for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Michigan 48202, USA.
Wei SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Raul TorresBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California 94158, USA.
Badri PadhukasahasramCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan 48202, USA.
Celeste EngDepartment of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
Delmy-Aracely Mejia-MejiaCentro de Neumologia y Alergias, San Pedro Sula 21102, Honduras.
Trevor FergusonTropical Medicine Research Institute, The University of the West Indies, St. Michael BB11115, Barbados.
Zhaohui S QinDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA.
Alan F ScottDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Maria YazdanbakhshDepartment of Parasitology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Javier MarrugoInstituto de Investigaciones Immunologicas, Universidad de Cartagena, Cartagena 130000, Colombia.
Leslie A LangeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Rajesh KumarDepartment of Pediatrics, Northwestern University, Chicago, Illinois 60637, USA.
Pedro C AvilaDepartment of Medicine, Northwestern University, Chicago, Illinois 60637, USA.
L Keoki WilliamsCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan 48202, USA.
Harold WatsonFaculty of Medical Sciences Cave Hill Campus, The University of the West Indies, Bridgetown BB11000, Barbados.
Lorraine B WareDepartment of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.
Christopher OlopadeDepartment of Medicine and Center for Global Health, University of Chicago, Chicago, Illinois 60637, USA.
Olufunmilayo OlopadeDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USA.
Ricardo OliveiraLaboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Salvador 40296-710, Brazil.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.
Dan L NicolaeDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USA.
Deborah MeyersCenter for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Alvaro MayorgaCentro de Neumologia y Alergias, San Pedro Sula 21102, Honduras.
Jennifer Knight-MaddenTropical Medicine Research Institute, The University of the West Indies, St. Michael BB11115, Barbados.
Tina HartertDepartment of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.
Nadia N HanselDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Marilyn G ForemanPulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA.
Jean G FordDepartment of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA.
Mezbah U FaruqueNational Human Genome Center, Howard University College of Medicine, Washington DC 20059, USA.
Georgia M DunstonNational Human Genome Center, Howard University College of Medicine, Washington DC 20059, USA.
Luis CaraballoInstitute for Immunological Research, Universidad de Cartagena, Cartagena 130000, Colombia.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
Eugene BleeckerCenter for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Maria Ilma AraujoImmunology Service, Universidade Federal da Bahia, Salvador 401110170, Brazil.
Edwin Francisco Herrera-PazCentro de Neumologia y Alergias, San Pedro Sula 21102, Honduras.
Kimberly GietzenIllumina, Inc., San Diego, California 92122, USA.
Wendy E GrusKnome Inc., Cambridge, Massachusetts 02141, USA.
Michael BamshadDepartment of Pediatrics, University of Washington, Seattle, Washington 98195, USA.
Carlos D BustamanteDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Eimear E KennyDepartment of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.
Ryan D HernandezDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, USA.
Terri H BeatyDepartment of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA.
Ingo RuczinskiDepartment of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA.
Joshua AkeyDepartment of Genomic Sciences, University of Washington, Seattle, Washington 98195, USA.
CAAPA
Kathleen C BarnesDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MViral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tina V Hartert · 2011 to 2026
$34.9MINSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MResearch Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI KLEMENT, BRENDA · 2012 to 2018
$24.8MNew Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI MANAMI HARA · 2013 to 2026
$20.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MSTRUCTURAL/FUNCTIONAL CHARACTERIZATION OF AMINOGLYCOSIDEG12RR003048 · NCRR · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 1985 to 2011
$19.0M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MNCATS NIH HHS UL1 TR000445NCI NIH HHS P50 CA125183NCI NIH HHS R21 CA178706NCI NIH HHS U01 CA161032NCRR NIH HHS G12 RR003048NCRR NIH HHS UL1 RR024975NHGRI NIH HHS R01 HG007644NHGRI NIH HHS R21 HG004751NHGRI NIH HHS R21 HG007233NHGRI NIH HHS T32 HG000044NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS K01 HL092601NHLBI NIH HHS K23 HL004464NHLBI NIH HHS R01 HL069167NHLBI NIH HHS R01 HL072414NHLBI NIH HHS R01 HL087699NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R21 HL112656NHLBI NIH HHS R37 HL068546NHLBI NIH HHS RC2 HL101543NHLBI NIH HHS RC2 HL101651NHLBI NIH HHS U01 HL049596NHLBI NIH HHS U01 HL081332NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U10 HL109164NIAID NIH HHS K24 AI077930NIAID NIH HHS R01 AI079139NIAID NIH HHS R01 AI114555NIAID NIH HHS U19 AI095227NIAID NIH HHS U19 AI095230NIDDK NIH HHS P30 DK020595NIEHS NIH HHS R01 ES015794NIGMS NIH HHS S06 GM008016NIGMS NIH HHS T32 GM007175NIMHD NIH HHS P60 MD006902NIMHD NIH HHS U54 MD007588Wellcome Trust
Abstract
The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry.
Indexed as
Gene FlowGenome, HumanHuman MigrationBase SequenceBlack PeopleDNA, IntergenicFemaleGenetic HeterogeneityGeographyHumansMalePhylogenyPolymorphism, Single NucleotideSexismDNA, Intergenic
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