Evidence map›Paper›PMID 27725661›Full record

ArticleMolecular psychiatry2017

Adenosine A

L Caetano, H Pinheiro, P Patrício, A Mateus-Pinheiro, N D Alves, B Coimbra, F I Baptista, S N Henriques, C Cunha, A R Santos and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Microglia as critical mediators linking perinatal immune stress to mental health trajectories.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Adenosinergic Modulation of Layer 6 Microcircuitry in the Medial Prefrontal Cortex Is Specific to Presynaptic Cell Type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Microglia-neuron interactions in schizophrenia.Frontiers in cellular neuroscience · 2024
    Review
  15. Review
  16. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

L CaetanoCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
H PinheiroInstitute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
P PatrícioLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
A Mateus-PinheiroLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
N D AlvesLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
B CoimbraLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
F I BaptistaInstitute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
S N HenriquesInstitute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
C CunhaICVS/3B's-PT Government Associate Laboratory, Guimarães, Portugal.ORCID 0000-0003-2550-6422
A R SantosICVS/3B's-PT Government Associate Laboratory, Guimarães, Portugal.
S G FerreiraCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
V M SardinhaLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
J F OliveiraLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
A F AmbrósioInstitute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
N SousaLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.ORCID 0000-0002-8755-5126
R A CunhaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
A J RodriguesLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.
L PintoLife and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal.ORCID 0000-0002-7724-0446
C A GomesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
University of Minho · PTUniversity of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developmental risk factors, such as the exposure to stress or high levels of glucocorticoids (GCs), may contribute to the pathogenesis of anxiety disorders. The immunomodulatory role of GCs and the immunological fingerprint found in animals prenatally exposed to GCs point towards an interplay between the immune and the nervous systems in the etiology of these disorders. Microglia are immune cells of the brain, responsive to GCs and morphologically altered in stress-related disorders. These cells are regulated by adenosine A

Indexed as

AnimalsAnxietyAnxiety DisordersCells, CulturedDexamethasoneFemaleGlucocorticoidsLipopolysaccharidesMaleMicrogliaPregnancyPrenatal Exposure Delayed EffectsRatsRats, WistarReceptor, Adenosine A2ASexismDexamethasoneGlucocorticoidsLipopolysaccharidesReceptor, Adenosine A2A

Identifiers

PMID27725661
OpenAlexW2531544330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.