ArticleMolecular psychiatry2017
Prospective associations of depression subtypes with cardio-metabolic risk factors in the general population.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Atypical depression is associated with metabolic syndrome: a systematic review.Actas espanolas de psiquiatria · 2022Pooled it
- The Prevalence of Cardiometabolic Health Risk Factors among Airline Pilots: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Inflammation and depression in young people: a systematic review and proposed inflammatory pathways.Molecular psychiatry · 2022Pooled it
- Changes in peripheral blood compounds following psychopharmacological treatment in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis.Psychological medicine · 2021Pooled it
- Understanding the relationship between type 2 diabetes and depression: lessons from genetically informative study designs.Diabetic medicine : a journal of the British Diabetic Association · 2021Pooled it
- Trial
- The moderating role of diet and physical activity in insulin resistance and immunometabolic depression.Scientific reports · 2025Article
- The association between dietary insulin index and load with depression, anxiety and stress in university students: a cross-sectional study.Scientific reports · 2025Article
- Discovery of Personalized Treatment for Immuno-Metabolic Depression-Focus on 11beta Hydroxysteroid Dehydrogenase Type 2 (11betaHSD2) and Toll-like Receptor 4 (TLR4) Inhibition with Enoxolone.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Physical, Cognitive, Social, and Functional Health Correlates of Major Depressive Disorder Subtypes: A Systematic Review.Brain sciences · 2025Review
- Bidirectional Associations Between Cardiometabolic Multimorbidity and Depression and Mediation of Lifestyles: A Multicohort Study.JACC. Asia · 2024Article
- Low-Grade Inflammation Associated with Major Depression Subtypes: A Cross-Sectional Study.Brain sciences · 2024Article
- Leptin's Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Dissecting the association between gut microbiota, body mass index and specific depressive symptoms: a mediation Mendelian randomisation study.General psychiatry · 2024Article
- Metabolomics signatures of depression: the role of symptom profiles.Translational psychiatry · 2023Article
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- The association between trauma exposure, polygenic risk and individual depression symptoms.Psychiatry research · 2023Article
- Healthy Nutrition, Physical Activity, and Sleep Hygiene to Promote Cardiometabolic Health of Airline Pilots: A Narrative Review.Journal of lifestyle medicine · 2023Review
- The Relationship Between Cardiovascular Disease Risk and Major Depression.Noro psikiyatri arsivi · 2023Article
- Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression.Journal of behavioral medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms and temporal sequence underlying the association between major depressive disorder (MDD) and cardio-metabolic diseases are still poorly understood. Recent research suggests subtyping depression to study the mechanisms underlying its association with biological correlates. Accordingly, our aims were to (1) assess the prospective associations of the atypical, melancholic and unspecified subtypes of MDD with changes of fasting glucose, high-density lipoprotein-cholesterol, triglycerides, systolic blood pressure and the incidence of the metabolic syndrome, (2) determine the potential mediating role of inflammatory marker or adipokine concentrations, eating behaviors and changes in waist circumference during follow-up. Data stemmed from CoLaus|PsyCoLaus, a prospective cohort study including 35-66-year-old randomly selected residents of an urban area. Among the Caucasian participants who underwent the physical and psychiatric baseline evaluations, 2813 (87% participation rate) also accepted the physical follow-up exam (mean follow-up duration=5.5 years). Symptoms of mental disorders were elicited using a semi-structured interview. The atypical MDD subtype, and only this subtype, was prospectively associated with a higher incidence of the metabolic syndrome (OR=2.49; 95% CI 1.30-4.77), a steeper increase of waist circumference (β=2.41; 95% CI 1.19-3.63) and independently of this, with a steeper increase of the fasting glucose level (β=131; 95% CI 38-225) during follow-up. These associations were not attributable to or mediated by inflammatory marker or adipokine concentrations, eating behaviors, comorbid psychiatric disorders or lifestyle factors. Accordingly, our results further support the subtyping of MDD and highlight the particular need for prevention and treatment of metabolic consequences in patients with atypical MDD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.