ArticleMolecular psychiatry2016
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Genetic correlation between smoking behaviors and schizophrenia.Schizophrenia research · 2018Pooled it
- Genetic foundations of interindividual neurophysiological variability.Science advances · 2025Article
- Genetic Foundations of Inter-individual Neurophysiological Variability.bioRxiv : the preprint server for biology · 2025Article
- The genetic relationships between brain structure and schizophrenia.Nature communications · 2023Article
- Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy.Scientific reports · 2023Article
- Enrichment of self-domestication and neural crest function loci in the heritability of neurodevelopmental disorders.Human genetics · 2023Article
- Lost in Translation: Challenges in the Diagnosis and Treatment of Early-Onset Schizophrenia.Cureus · 2023Review
- Genetic map of regional sulcal morphology in the human brain from UK biobank data.Nature communications · 2022Article
- A cognitive neurogenetic approach to uncovering the structure of executive functions.Nature communications · 2022Article
- Age-dependent effects of schizophrenia genetic risk on cortical thickness and cortical surface area: Evaluating evidence for neurodevelopmental and neurodegenerative models of schizophrenia.Journal of psychopathology and clinical science · 2022Article
- Article
- Associations Between Traumatic Stress, Brain Volumes and Post-traumatic Stress Disorder Symptoms in Children: Data from the ABCD Study.Behavior genetics · 2022Article
- Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex.NeuroImage · 2021Article
- Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder.Molecular psychiatry · 2021Article
- Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci.Biological psychiatry · 2021Article
- Partitioning heritability analyses unveil the genetic architecture of human brain multidimensional functional connectivity patterns.Human brain mapping · 2020Article
- Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology.Nature reviews. Neurology · 2020Review
- Current challenges and possible future developments in personalized psychiatry with an emphasis on psychotic disorders.Heliyon · 2020Review
Corrections and comments
- Erratum issuedPartitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.2017 · Martin, N H [corrected to Martin, N G]
Authors and funding
19 authors.
Funding
Abstract
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic etiology. Widespread cortical gray matter loss has been observed in patients and prodromal samples. However, it remains unresolved whether schizophrenia-associated cortical structure variations arise due to disease etiology or secondary to the illness. Here we address this question using a partitioning-based heritability analysis of genome-wide single-nucleotide polymorphism (SNP) and neuroimaging data from 1750 healthy individuals. We find that schizophrenia-associated genetic variants explain a significantly enriched proportion of trait heritability in eight brain phenotypes (false discovery rate=10%). In particular, intracranial volume and left superior frontal gyrus thickness exhibit significant and robust associations with schizophrenia genetic risk under varying SNP selection conditions. Cross-disorder comparison suggests that the neurogenetic architecture of schizophrenia-associated brain regions is, at least in part, shared with other psychiatric disorders. Our study highlights key neuroanatomical correlates of schizophrenia genetic risk in the general population. These may provide fundamental insights into the complex pathophysiology of the illness, and a potential link to neurocognitive deficits shaping the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.