Evidence map›Paper›PMID 27725655›Full record

ArticleMolecular psychiatry2017

Structural brain changes are associated with response of negative symptoms to prefrontal repetitive transcranial magnetic stimulation in patients with schizophrenia.

A Hasan, T Wobrock, B Guse, B Langguth, M Landgrebe, P Eichhammer, E Frank, J Cordes, W Wölwer, F Musso and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  16. Repetitive Transcranial Magnetic Stimulation as a Therapeutic and Probe in Schizophrenia: Examining the Role of Neuroimaging and Future Directions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

A HasanDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
T WobrockDepartment of Psychiatry and Psychotherapy, Georg-August-University Göttingen, Göttingen, Germany.
B GuseDepartment of Psychiatry and Psychotherapy, Georg-August-University Göttingen, Göttingen, Germany.
B LangguthDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
M LandgrebeDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
P EichhammerDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
E FrankDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
J CordesDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
W WölwerDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
F MussoDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
G WintererExperimental and Clinical Research Centre, The Charité - Universitätsmedizin Berlin, Berlin, Germany.
W GaebelDepartment of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
G HajakDepartment of Psychiatry, Psychosomatics and Psychotherapy, Sozialstiftung Bamberg, Bamberg, Germany.
C OhmannEuropean Clinical Research Network, Düsseldorf, Germany.
P E VerdeCoordination Centre for Clinical Trials, Heinrich-Heine University, Düsseldorf, Germany.
M RietschelDepartment of Genetic Epidemiology in Psychiatry, Institute of Central Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
R AhmedInstitut für anwendungsorientierte Forschung und klinische Studien GmbH, Göttingen, Germany.
W G HonerDepartment of Genetic Epidemiology in Psychiatry, Institute of Mental Health, The University of British Columbia, Vancouver, BC, Canada.
P DechentDepartment of Cognitive Neurology, Georg-August-University Goettingen, Goettingen, Germany.
B MalchowDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
M F U CastroDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
D DwyerDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
C CabralDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
P M KreuzerDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
T B PoepplDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
T Schneider-AxmannDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
P FalkaiDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
N KoutsoulerisDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired neural plasticity may be a core pathophysiological process underlying the symptomatology of schizophrenia. Plasticity-enhancing interventions, including repetitive transcranial magnetic stimulation (rTMS), may improve difficult-to-treat symptoms; however, efficacy in large clinical trials appears limited. The high variability of rTMS-related treatment response may be related to a comparably large variation in the ability to generate plastic neural changes. The aim of the present study was to determine whether negative symptom improvement in schizophrenia patients receiving rTMS to the left dorsolateral prefrontal cortex (DLPFC) was related to rTMS-related brain volume changes. A total of 73 schizophrenia patients with predominant negative symptoms were randomized to an active (n=34) or sham (n=39) 10-Hz rTMS intervention applied 5 days per week for 3 weeks to the left DLPFC. Local brain volume changes measured by deformation-based morphometry were correlated with changes in negative symptom severity using a repeated-measures analysis of covariance design. Volume gains in the left hippocampal, parahippocampal and precuneal cortices predicted negative symptom improvement in the active rTMS group (all r⩽-0.441, all P⩽0.009), but not the sham rTMS group (all r⩽0.211, all P⩾0.198). Further analyses comparing negative symptom responders (⩾20% improvement) and non-responders supported the primary analysis, again only in the active rTMS group (F

Indexed as

AdultBrainDouble-Blind MethodFemaleHumansMaleNeuronal PlasticityPrefrontal CortexPsychiatric Status Rating ScalesSchizophreniaTranscranial Magnetic StimulationTreatment Outcome

Identifiers

PMID27725655

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.