ArticleThe American journal of gastroenterology2016
Oral Contraceptive Use and Risk of Ulcerative Colitis Progression: A Nationwide Study.
Article in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Using natural language processing to extract information from clinical text in electronic medical records for populating clinical registries: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2026Pooled it
- Contraceptive use among women with inflammatory bowel disease: An updated systematic review.Contraception · 2025Pooled it
- Sex-related differences in profiles and clinical outcomes of Inflammatory bowel disease: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- Evidence-based clinical practice guidelines for inflammatory bowel disease 2020.Journal of gastroenterology · 2021Review
- Sex-based differences in inflammatory bowel diseases: a review.Therapeutic advances in gastroenterology · 2020Review
- The longitudinal integrated database for health insurance and labour market studies (LISA) and its use in medical research.European journal of epidemiology · 2019Review
- Need of informatics in designing interoperable clinical registries.International journal of medical informatics · 2017Article
- Elderly-Onset and Adult-Onset Ulcerative Colitis Are More Similar than Previously Reported in a Nationwide Cohort.Digestive diseases and sciences · 2017Article
- Modifiable Environmental Factors in Inflammatory Bowel Disease.Current gastroenterology reports · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesOral contraceptive (OC) use has been consistently linked to increased risk of inflammatory bowel disease. Nonetheless, a specific role of OC in the natural history of ulcerative colitis (UC) is unknown.
methodsWe identified 6,104 incident female UC cases aged 16-51 years at diagnosis from the Swedish National Patient Register starting in January of 2003. Information on current OC use was obtained from the Prescribed Drug Register starting in July of 2005. We followed cases through December of 2014 for primary outcome defined as first UC-related surgery, and the secondary outcomes defined by recipient of the first prescription of oral steroids or anti-tumor necrosis factor (anti-TNF) use. We used Cox proportional hazard modeling with time-varying covariates to estimate multivariable-adjusted hazard ratio (aHR) and 95% confidence interval (CI).
resultsOver 31,421 person-years of follow up, we observed 162 cases of UC-related surgery. Compared with nonusers, current and past use of OC were not significantly associated with risk of UC-related surgery (aHR=0.79; 95% CI, 0.52-1.18; and aHR=0.74, 95% CI, 0.46-1.18, respectively). The association did not appear to be modified by type of OC use (progestin-only vs. combination of progestin and estrogen), longer duration of use, or higher number of dispensed prescriptions (All P
conclusionsIn a large nationwide registry of UC patients, we found no association between OC use and UC progression. Our data offer reassurance regarding the safety of OC assessed by its effect on risk of surgery and steroid or anti-TNF use in women with established UC.
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