Evidence map›Paper›PMID 27725470›Full record

ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2016

Total synthesis and related studies of large, strained, and bioactive natural products.

Masahiro Hirama

Abstract readReview
In one paragraph

Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Conformational constraint in natural product synthesis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025
    Review
  3. Article
  4. At the dawn of novel aromatics: "On the Synthesis of Hinokitiol" by Tetsuo Nozoe et al.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Masahiro HiramaDepartment of Chemistry, Graduate School of Science, Tohoku University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our chemical syntheses and related scientific investigations of natural products with complex architectures and powerful biological activities are described, focusing on the very large 3 nm-long polycyclic ethers called the ciguatoxins, highly strained and labile chromoprotein antitumor antibiotics featuring nine-membered enediyne cores, and extremely potent anthelmintic macrolides called the avermectins.

Indexed as

Antineoplastic AgentsBiocompatible MaterialsBiological ProductsCiguatoxinsMolecular ConformationStereoisomerismAntineoplastic AgentsBiocompatible MaterialsBiological ProductsCiguatoxins

Identifiers

PMID27725470
PMCPMC5243947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.