Evidence map›Paper›PMID 27725162›Full record

ArticleEuropean journal of pharmacology2016

The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca

Harry Z E Greenberg, Kazi S Jahan, Jian Shi, W-S Vanessa Ho, Anthony P Albert

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Cardioprotective Role of CalhexCell biochemistry and biophysics · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Role of the calcium-sensing receptor in regulating vascular function.Journal of cell communication and signaling · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Harry Z E GreenbergVascular Biology Research Centre, Institute of Cardiovascu lar & Cell Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address: m0600877@sgul.ac.uk.
Kazi S JahanVascular Biology Research Centre, Institute of Cardiovascu lar & Cell Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Jian ShiVascular Biology Research Centre, Institute of Cardiovascu lar & Cell Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
W-S Vanessa HoVascular Biology Research Centre, Institute of Cardiovascu lar & Cell Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Anthony P AlbertVascular Biology Research Centre, Institute of Cardiovascu lar & Cell Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
St George's, University of London · GB

Funding

British Heart Foundation FS/13/10/30021British Heart Foundation FS/15/44/31570
6 · The paper itself

Abstract

The present study investigates the effect of commonly used negative and positive allosteric modulators of the calcium-sensing receptor (CaSR) on vascular reactivity. In wire myography studies, increasing [Ca

Indexed as

AnimalsBenzamidesCalcimimetic AgentsCalciumCalcium Channel BlockersCalcium ChannelsCyclohexylaminesDose-Response Relationship, DrugExtracellular SpaceIndolesMaleMesenteric ArteriesMethoxamineNaphthalenesPotassium ChlorideRabbitsBenzamidesCalcimimetic AgentsCalciumCalcium Channel BlockersCalcium ChannelsCyclohexylaminesIndolesMethoxamineN(1)-(4-chlorobenzoyl)-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexaneN-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamineNaphthalenesPotassium Chloride(R)-2-(1-(1-naphthyl)ethyl-aminom-ethyl)indoleReceptors, Calcium-SensingCalcilyticCalcimimeticCalcium-sensing receptorCalhex-231CalindolNPS 2143

Identifiers

PMID27725162
PMCPMC5127511
OpenAlexW2530128254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.