Evidence map›Paper›PMID 27725125›Full record

ArticleJournal of neuroimmunology2016

Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4.

Mario A Pulido, Meleeneh Kazarian DerHartunian, Zhenxia Qin, Eric M Chung, Diane S Kang, Andrew W Woodham, Jeffrey A Tsou, Rinse Klooster, Omid Akbari, Lina Wang and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Mario A Pulido *Departments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Meleeneh Kazarian DerHartunian *Departments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Zhenxia QinDepartment of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, CA.
Eric M ChungDepartments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Diane S KangDepartments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Andrew W WoodhamDepartment of Molecular Microbiology and Immunology Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Jeffrey A TsouDepartments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Rinse KloosterDepartments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Omid AkbariDepartment of Molecular Microbiology and Immunology Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Lina WangDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
W Martin KastDepartment of Molecular Microbiology and Immunology Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Stephen V LiuDepartment of Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Jan J G M VerschuurenDepartment of Neurology, Leiden University, Leiden, the Netherlands.
Dana W AswadDepartment of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, CA.
Ite A Laird-OffringaDepartments of Surgery and of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
University of Southern California · USUniversity of California, Irvine · USLeiden University · NL

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Genetic and Environmental Determinants of Asthma EndophenotypesR01ES025786 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2015 to 2019
$2.8M
Protein Methylation in BrainR01NS017269 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ASWAD, DANA WILLIAM · 1985 to 2012
$2.4M
Identification of Protein Drug Leads That Address Challenges to Small Molecule CeR01GM107520 · NIGMS · COLORADO STATE UNIVERSITY · PI KENNAN, ALAN J · 2014 to 2018
$1.4M
Southern California Clinical and Translational Science InstituteTL1TR000132 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2014
$491k
NCATS NIH HHS TL1 TR000132NCI NIH HHS P30 CA014089NIEHS NIH HHS R01 ES025786NIGMS NIH HHS R01 GM107520NINDS NIH HHS R01 NS017269
6 · The paper itself

Abstract

Autoantibodies against SCLC-associated neuronal antigen ELAVL4 (HuD) have been linked to smaller tumors and improved survival, but the antigenic epitope and mechanism of autoimmunity have never been solved. We report that recombinant human ELAVL4 protein incubated under physiological conditions acquires isoaspartylation, a type of immunogenic protein damage. Specifically, the N-terminal region of ELAVL4, previously implicated in SCLC-associated autoimmunity, undergoes isoaspartylation in vitro, is recognized by sera from anti-ELAVL4 positive SCLC patients and is highly immunogenic in subcutaneously injected mice and in vitro stimulated human lymphocytes. Our data suggest that isoaspartylated ELAVL4 is the trigger for the SCLC-associated anti-ELAVL4 autoimmune response.

Indexed as

AdultAgedAmino Acid SequenceAnimalsAutoimmunityELAV-Like Protein 4FemaleHumansLung NeoplasmsMaleMiceMice, KnockoutMiddle AgedNeuronsRabbitsSmall Cell Lung CarcinomaELAVL4 protein, humanELAV-Like Protein 4AutoimmunityIsoaspartylationSCLCSmall cell lung cancer

Identifiers

PMID27725125
PMCPMC5152694
OpenAlexW2512594882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.