ArticleeLife2016
An excitatory cortical feedback loop gates retinal wave transmission in rodent thalamus.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
- Premature vision drives aberrant development of response properties in primary visual cortex.eLife · 2025Article
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- Cholinergic Waves Have a Modest Influence on the Transcriptome of Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Premature vision drives aberrant development of response properties in primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Auditory evoked delta brushes involve stimulus-specific cortical networks in preterm infants.iScience · 2025Article
- Activity-Dependent Synapse Refinement: From Mechanisms to Molecules.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Unsupervised learning on spontaneous retinal activity leads to efficient neural representation geometry.ArXiv · 2023Article
- Cortical activity emerges in region-specific patterns during early brain development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Cortical activity emerges in region-specific patterns during early brain development.bioRxiv : the preprint server for biology · 2023Article
- Building thalamic neuronal networks during mouse development.Frontiers in neural circuits · 2023Review
- Thalamocortical circuits for the formation of hierarchical pathways in the mammalian visual cortex.Frontiers in neural circuits · 2023Review
- Cortical Cross-Frequency Coupling Is Affected byFrontiers in neuroscience · 2022Article
- The organization and development of cortical interneuron presynaptic circuits are area specific.Cell reports · 2021Article
- Review
- Sensory Coding of Limb Kinematics in Motor Cortex across a Key Developmental Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Network Dynamics in the Developing Piriform Cortex of Unanesthetized Rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity.Frontiers in molecular neuroscience · 2021Article
Corrections and comments
- Commented on byCatching a wave.2016
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Spontaneous retinal waves are critical for the development of receptive fields in visual thalamus (LGN) and cortex (VC). Despite a detailed understanding of the circuit specializations in retina that generate waves, whether central circuit specializations also exist to control their propagation through visual pathways of the brain is unknown. Here we identify a developmentally transient, corticothalamic amplification of retinal drive to thalamus as a mechanism for retinal wave transmission in the infant rat brain. During the period of retinal waves, corticothalamic connections excite LGN, rather than driving feedforward inhibition as observed in the adult. This creates an excitatory feedback loop that gates retinal wave transmission through the LGN. This cortical multiplication of retinal wave input ends just prior to eye-opening, as cortex begins to inhibit LGN. Our results show that the early retino-thalamo-cortical circuit uses developmentally specialized feedback amplification to ensure powerful, high-fidelity transmission of retinal activity despite immature connectivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.