Trial reportTrials2016
Effects of probiotics (Vivomixx®) in obese pregnant women and their newborn: study protocol for a randomized controlled trial.
Trial report in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02508844 (The POP-study), which is not on this map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The POP-study: Effect of Probiotics on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn - a Randomized, Double-blind Placebo Controlled Trial With Vivomixx®
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The Influences of Oral Probiotics on the Immunometabolic Response During Pregnancy and Lactation: A Systematic Review.Nutrients · 2025Pooled it
- Meta-analysis of probiotic metabolites in the prevention of gestational weight gain and postpartum weight retention.Frontiers in cellular and infection microbiology · 2025Pooled it
- The effect of probiotics on gestational diabetes and its complications in pregnant mother and newborn: A systematic review and meta-analysis during 2010-2020.Journal of clinical laboratory analysis · 2022Pooled it
- Probiotics for preventing gestational diabetes.The Cochrane database of systematic reviews · 2021Pooled it
- Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2018Pooled it
- Trial
- Nutraceuticals in Pregnancy: A Special Focus on Probiotics.International journal of molecular sciences · 2024Review
- Gut Microbiota Modulation in the Management of Chronic Obstructive Pulmonary Disease: A Literature Review.Cureus · 2024Review
- Interaction and Metabolic Pathways: Elucidating the Role of Gut Microbiota in Gestational Diabetes Mellitus Pathogenesis.Metabolites · 2024Review
- Broadening horizons: intestinal microbiota as a novel biomarker and potential treatment for hypertensive disorders of pregnancy.Frontiers in cellular and infection microbiology · 2024Review
- Expression of Concern on "A Review on Role of Microbiome in Obesity and Antiobesity Properties of Probiotic Supplements".BioMed research international · 2022Article
- Effects of nutritional interventions during pregnancy on birth, child health and development outcomes: A systematic review of evidence from low- and middle-income countries.Campbell systematic reviews · 2021Article
- The impact of maternal obesity on childhood neurodevelopment.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Maternal microbiome in preeclampsia pathophysiology and implications on offspring health.Physiological reports · 2021Review
- Gestational gut microbial remodeling is impaired in a rat model of preeclampsia superimposed on chronic hypertension.Physiological genomics · 2021Article
- Probiotics for the Treatment of Overweight and Obesity in Humans-A Review of Clinical Trials.Microorganisms · 2020Review
- Multistrain Probiotic Increases the Gut Microbiota Diversity in Obese Pregnant Women: Results from a Randomized, Double-Blind Placebo-Controlled Study.Current developments in nutrition · 2020Article
- Article
- A Review on Role of Microbiome in Obesity and Antiobesity Properties of Probiotic Supplements.BioMed research international · 2019Review
- Obesity and gut microbiome: review of potential role of probiotics.Porto biomedical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMaternal obesity is associated with increased risks of adverse pregnancy-related complications and outcomes for both mothers and infants. Overweight and obese women have an increased risk of pregnancy-induced hypertension, preeclampsia and gestational diabetes mellitus (GDM). Infant Body Mass index (BMI) and the risk of obesity in adulthood are related to maternal gestational weight gain (GWG). Preventive lifestyle and dietary interventions are time-consuming and do not always reduce GWG or the risk of maternal pregnancy complications. Recent research has indicated that the gut microbiota may play a significant role in the development of obesity. Some studies have indicated that the daily consumption of probiotics may reduce the risk of preeclampsia, maintain serum insulin levels and reduce the frequency of GDM in pregnant women. The aims of this study are to investigate whether daily probiotic supplements in obese women during pregnancy can limit gestational weight gain, improve glucose homeostasis and thereby improve maternal, fetal and infant health outcomes.
methodsA pilot study including 50 obese pregnant nulliparous women with a prepregnancy BMI of between 30 and 35 kg/m DISCUSSION: We expect to find alterations in the metabolic profiles, microbiota and possibly pregnancy outcomes. From a clinical point of view the effects of Vivomixx® could control weight gain and reduce complications during pregnancy by inducing changes in the gut microbiota. Furthermore, this intervention during pregnancy could influence the infant's microbiota, which could have important implications for infant development and health.
trial registrationClincalTrials.gov Identifier: NCT02508844 , registered on 11 May 2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.