SynthesisBMC infectious diseases2016
Does cemented or cementless single-stage exchange arthroplasty of chronic periprosthetic hip infections provide similar infection rates to a two-stage? A systematic review.
Synthesis in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The heavy burden and treatment challenges of fungal periprosthetic joint infection: a systematic review of 489 joints.BMC musculoskeletal disorders · 2024Pooled it
- Meta-analysis in periprosthetic joint infection: a global bibliometric analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- One- vs. Two-Stage Exchange for Chronic Hip Periprosthetic Joint Infection: A Framework Based on Patient Treatment Burden and Institutional Capability.JBJS reviews · 2026Review
- Partial versus full revision in cementless single-stage exchange for hip periprosthetic joint infection: a multicenter comparative study with 10-year survivorship analysis.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Article
- What Is the Role of Local Antimicrobial Protection for One-Stage Revision for Peri-Prosthetic Hip Infection?Antibiotics (Basel, Switzerland) · 2024Review
- Clinician-driven research priorities in bone and joint infection: perspectives of orthopaedic surgeons and infectious diseases physicians.ANZ journal of surgery · 2022Article
- Reimplantation after Periprosthetic Joint Infection: The Role of Microbiology.Antibiotics (Basel, Switzerland) · 2022Article
- Megaprostheses for the revision of infected hip arthroplasties with severe bone loss.BMC surgery · 2022Article
- Periprosthetic Joint Infection (PJI)-Results of One-Stage Revision with Antibiotic-Impregnated Cancellous Allograft Bone-A Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2022Article
- The '2-in-1' stage: indications, technique & results.Annals of joint · 2022Review
- New Technique for Custom-Made Spacers in Septic Two-Stage Revision of Total Hip Arthroplasties.Antibiotics (Basel, Switzerland) · 2021Article
- Improving outcomes in acute and chronic periprosthetic hip and knee joint infection with a multidisciplinary approach.Bone & joint open · 2021Article
- Management of peri-prosthetic joint infection and severe bone loss after total hip arthroplasty using a long-stemmed cemented custom-made articulating spacer (CUMARS).BMC musculoskeletal disorders · 2021Article
- [Periprosthetic joint infections : Latest developments, strategies and treatment algorithms].Der Orthopade · 2020Review
- Low-dose vancomycin-loaded cement spacer for two-stage revision of infected total hip arthroplasty.Joint diseases and related surgery · 2020Article
- Two-stage cementless hip revision for peri-prosthetic infection with an antibacterial hydrogel coating: results of a comparative series.International orthopaedics · 2019Article
- One-stage exchange with antibacterial hydrogel coated implants provides similar results to two-stage revision, without the coating, for the treatment of peri-prosthetic infection.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification.World journal of orthopedics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe best surgical modality for treating chronic periprosthetic hip infections remains controversial, with a lack of randomised controlled studies. The aim of this systematic review is to compare the infection recurrence rate after a single-stage versus a two-stage exchange arthroplasty, and the rate of cemented versus cementless single-stage exchange arthroplasty for chronic periprosthetic hip infections.
methodsWe searched for eligible studies published up to December 2015. Full text or abstract in English were reviewed. We included studies reporting the infection recurrence rate as the outcome of interest following single- or two-stage exchange arthroplasty, or both, with a minimum follow-up of 12 months. Two reviewers independently abstracted data and appraised quality assessment.
resultsAfter study selection, 90 observational studies were included. The majority of studies were focused on a two-stage hip exchange arthroplasty (65 %), 18 % on a single-stage exchange, and only a 17 % were comparative studies. There was no statistically significant difference between a single-stage versus a two-stage exchange in terms of recurrence of infection in controlled studies (pooled odds ratio of 1.37 [95 % CI = 0.68-2.74, I
conclusionDespite the methodological limitations and the heterogeneity between single cohorts studies, if we considered only the available controlled studies no superiority was demonstrated between a single- and two-stage exchange at a minimum of 12 months follow-up. The overalapping of confidence intervals related to single-stage cementless and cemented hip exchanges, showed no superiority of either technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.