ArticleBMC gastroenterology2016
The dual role of Escherichia coli in the course of ulcerative colitis.
Article in BMC gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Deciphering the Implications ofPathogens (Basel, Switzerland) · 2026Review
- Angelicin: A promising tricyclic aromatic agent for ulcerative colitis through cysteine-mediated proliferation of intestinal epithelial cells.Journal of pharmaceutical analysis · 2026Article
- Impact of gut microbiome on atrial fibrillation: Mechanistic insights and future directions in individualized medicine.World journal of cardiology · 2025Review
- UropathogenicInternational journal of molecular sciences · 2025Article
- Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Importance of Lactobacilli for Human Health.Microorganisms · 2024Review
- Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases.International journal of molecular sciences · 2024Review
- Effect of tofacitinib on the phenotype and activity of Caco‑2 cells in a model of inflammatory bowel disease.Experimental and therapeutic medicine · 2024Article
- The influence of microbiota on ferroptosis in intestinal diseases.Gut microbes · 2023Review
- AreFoods (Basel, Switzerland) · 2022Article
- Impact of Obesity on the Course of Management of Inflammatory Bowel Disease-A Review.Nutrients · 2022Review
- Molecular detection of pathogenic bacteria in the colonic biopsies from patients with Ulcerative Colitis.African health sciences · 2022Article
- Article
- Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.Redox biology · 2020Article
- Relationship(s) between obesity and inflammatory bowel diseases: possible intertwined pathogenic mechanisms.Clinical journal of gastroenterology · 2020Review
- Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.Inflammatory bowel diseases · 2018Article
- Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study examines the dual role of Escherichia coli in the course of ulcerative colitis (UC). The intestinal microbiota is considered to play an important role in UC pathogenesis, but how E. coli contributes to inflammation in UC is still unknown. On the one hand, we demonstrated that there was a significant increase in the number of E. coli at the sites of inflammation in patients with UC, which can lead to immune system activation, whilst, on the other hand, E. coli may contribute to the resolution of inflammatory reactions since E. coli can inhibit hydroxyl radical formation by eliminating substrates of the Fenton reaction, by assimilating ferrous iron (Fe
methodsTen E. coli strains were isolated from the colonic mucosa of patients in the acute phase of UC. Using PCR, we examined the presence of genes encoding catalases (katG and katE) and proteins participating in iron acquisition (feoB, fepA, fhuA, fecA, iroN, fyuA, and iutA) in these E. coli strains. To determine if iron ions influence the growth rate of E. coli and its ability to decompose H
resultsAll investigated E. coli strains had catalase genes (katG, katE), genes coding for receptors for Fe
conclusionsE. coli eliminates substrates of the Fenton reaction by assimilating Fe
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.