Observational studyJAMA internal medicine2016
Receipt of Antibiotics in Hospitalized Patients and Risk for Clostridium difficile Infection in Subsequent Patients Who Occupy the Same Bed.
Observational study in JAMA internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Indirect effect of oral azithromycin on the gut resistome of untreated children: a randomized controlled trial.International health · 2021Trial
- Evaluation of endoscopic processing on the potential forInfection prevention in practice · 2026Article
- Understanding antibiotic prescribing in the inpatient setting: a synthesis of evidence on determinants and interventions.Antimicrobial resistance and infection control · 2026Article
- Institutional spillover effects of antimicrobial use on antimicrobial resistance andAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Changes in the Epidemiology of Clostridioides difficile Infection.Infectious disease clinics of North America · 2025Review
- Isolation ofAnimals : an open access journal from MDPI · 2025Article
- Integrating Nonindividual Patient Features in Machine Learning Models of Hospital-Onset Bacteremia.JAMA network open · 2025Article
- The role of the hospital bed in hospital-onsetInfection control and hospital epidemiology · 2024Article
- Diagnostic stewardship to improve patient outcomes and healthcare-associated infection (HAI) metrics.Infection control and hospital epidemiology · 2024Article
- Describing the monthly variability of hospital-onsetInfection control and hospital epidemiology · 2024Article
- Environmental approaches to controlling Clostridioides difficile infection in healthcare settings.Antimicrobial resistance and infection control · 2023Review
- Role of previous systemic antibiotic therapy on the probability of recurrence after an initial episode ofJAC-antimicrobial resistance · 2023Article
- Nightmare in the ward: difficultEuropean heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Mitigating hospital-onsetInfection control and hospital epidemiology · 2023Article
- How Does Hospital Microbiota Contribute to Healthcare-Associated Infections?Microorganisms · 2023Review
- Article
- A novel approach to correcting attribution ofAntimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Retrospective Study of the Epidemiology ofInfection and drug resistance · 2023Article
- Repurposing epigenetic inhibitors to target theEpigenetics · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo assess whether receipt of antibiotics by prior hospital bed occupants is associated with increased risk for CDI in subsequent patients who occupy the same bed. DESIGN, SETTING, AND
participantsThis is a retrospective cohort study of adult patients hospitalized in any 1 of 4 facilities between 2010 and 2015. Patients were excluded if they had recent CDI, developed CDI within 48 hours of admission, had inadequate follow-up time, or if their prior bed occupant was in the bed for less than 24 hours. MAIN OUTCOMES AND MEASURES: The primary exposure was receipt of non-CDI antibiotics by the prior bed occupant and the primary outcome was incident CDI in the subsequent patient to occupy the same bed. Incident CDI was defined as a positive result from a stool polymerase chain reaction for the C difficile toxin B gene followed by treatment for CDI. Demographics, comorbidities, laboratory data, and medication exposures are reported.
resultsAmong 100 615 pairs of patients who sequentially occupied a given hospital bed, there were 576 pairs (0.57%) in which subsequent patients developed CDI. Receipt of antibiotics in prior patients was significantly associated with incident CDI in subsequent patients (log-rank P < .01). This relationship remained unchanged after adjusting for factors known to influence risk for CDI including receipt of antibiotics by the subsequent patient (adjusted hazard ratio [aHR], 1.22; 95% CI, 1.02-1.45) and also after excluding 1497 patient pairs among whom the prior patients developed CDI (aHR, 1.20; 95% CI, 1.01-1.43). Aside from antibiotics, no other factors related to the prior bed occupants were associated with increased risk for CDI in subsequent patients. CONCLUSIONS AND RELEVANCE: Receipt of antibiotics by prior bed occupants was associated with increased risk for CDI in subsequent patients. Antibiotics can directly affect risk for CDI in patients who do not themselves receive antibiotics.
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