ArticlePloS one2016
Piscirickettsia salmonis Imbalances the Innate Immune Response to Succeed in a Productive Infection in a Salmonid Cell Line Model.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Synergistic Protection of Atlantic Salmon Against Caligus Rogercresseyi and Piscirickettsia Salmonis Using IPath® and Commercial Vaccines.Marine biotechnology (New York, N.Y.) · 2026Article
- Rearing system type affects baseline and post-vaccination immune gene expression in Atlantic salmon gills during smoltification.Veterinarni medicina · 2026Article
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- Silybin Interferes with the Intracellular Replication ofAntibiotics (Basel, Switzerland) · 2026Article
- Gene expression patterns of immune markers in rainbow trout during the early stages of seawater infections withFrontiers in veterinary science · 2025Article
- Salmonid Rickettsial Septicemia (SRS) disease dynamics and Atlantic salmon immune response to Piscirickettsia salmonis LF-89 and EM-90 co-infection.Veterinary research · 2024Article
- Immunomodulation Evidence of Nanostructured Recombinant Proteins in Salmonid Cells.Animals : an open access journal from MDPI · 2024Article
- In Vivo Efficacy of Purified Quillaja Saponin Extracts in Protecting againstAnimals : an open access journal from MDPI · 2023Article
- KLF17 is an important regulatory component of the transcriptomic response of Atlantic salmon macrophages toFrontiers in immunology · 2023Article
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- Immune Modulation Ability of Hepcidin from Teleost Fish.Animals : an open access journal from MDPI · 2022Article
- Why DoesFrontiers in immunology · 2022Review
- Why vaccines fail againstFrontiers in immunology · 2022Review
- Gut Associated Lymphoid Tissue (GALT) primary cells and stable cell lines as predictive models for intestinal health in rainbow trout (Frontiers in immunology · 2022Article
- Comparative Analysis of Salmon Cell Lines and Zebrafish Primary Cell Cultures Infection with the Fish PathogenMicroorganisms · 2021Article
- RNA-Seq-Based Analysis of Cortisol-Induced Differential Gene Expression Associated withAnimals : an open access journal from MDPI · 2021Article
- The Phagosome-Lysosome Fusion Is the Target of a PurifiedAntibiotics (Basel, Switzerland) · 2021Article
- "Limiting access to iron decreases infection of Atlantic salmon SHK-1 cells with bacterium Piscirickettsia salmonis".BMC veterinary research · 2021Article
- The Analysis of Live-AttenuatedMicroorganisms · 2021Article
- Comparison of Circulating Markers and Mucosal Immune Parameters from Skin and Distal Intestine of Atlantic Salmon in Two Models of Acute Stress.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Piscirickettsia salmonis is a facultative intracellular bacterium that causes the disease called "salmon rickettsial syndrome". Attempts to control this disease have been unsuccessful, because existing vaccines have not achieved the expected effectiveness and the antibiotics used fail to completely eradicate the pathogen. This is in part the product of lack of scientific information that still lacks on the mechanisms used by this bacterium to overcome infected-cell responses and survive to induce a productive infection in macrophages. For that, this work was focused in determining if P. salmonis is able to modify the expression and the imbalance of IL-12 and IL-10 using an in vitro model. Additionally, we also evaluated the role the antimicrobial peptide hepcidin had in the control of this pathogen in infected cells. Therefore, the expression of IL-10 and IL-12 was evaluated at earlier stages of infection in the RTS11 cell line derived from Oncorhynchus mykiss macrophages. Simultaneously, the hepcidin expression and location was analyzed in the macrophages infected with the pathogen. Our results suggest that IL-10 is clearly induced at early stages of infection with values peaking at 36 hours post infection. Furthermore, infective P. salmonis downregulates the expression of antimicrobial peptide hepcidin and vesicles containing this peptide were unable to merge with the infective bacteria. Our results suggest that P. salmonis is able to manipulate the behavior of host cytokines and likely might constitute a virulence mechanism that promotes intracellular bacterial replication in leukocytes cells lines of trout and salmon. This mechanism involves the generation of an optimum environment for the microorganism and the downregulation of antimicrobial effectors like hepcidin.
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