ArticlePloS one2016
More than 50% of Clostridium difficile Isolates from Pet Dogs in Flagstaff, USA, Carry Toxigenic Genotypes.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 70 citations in OpenAlex.
- One Health genomic insights into environmental and animal reservoirs of community-associatedApplied and environmental microbiology · 2026Article
- Pangenome-GWAS analysis ofCanadian journal of microbiology · 2026Article
- Pathogen Detection and Resistome Analysis in Healthy Shelter Dogs Using Whole Metagenome Sequencing.Pathogens (Basel, Switzerland) · 2025Article
- Culture-independent detection of low-abundantApplied and environmental microbiology · 2024Article
- Microbial assessment of commercial pet foods marketed in the United Arab Emirates.Frontiers in veterinary science · 2024Article
- Update on Commonly Used Molecular Typing Methods forMicroorganisms · 2023Review
- Infrequent intrahousehold transmission of Clostridioides difficile between pet owners and their pets.Zoonoses and public health · 2023Article
- A local-scale One Health genomic surveillance ofMicrobial genomics · 2023Article
- Dogs as carriers of virulent and resistant genotypes of Clostridioides difficile.Zoonoses and public health · 2022Article
- Diverse lineages of pathogenic Leptospira species are widespread in the environment in Puerto Rico, USA.PLoS neglected tropical diseases · 2022Article
- Genetic and phenotypic characteristics of Clostridium (Clostridioides) difficile from canine, bovine, and pediatric populations.Anaerobe · 2022Article
- Global evolutionary dynamics and resistome analysis ofMicrobial genomics · 2022Article
- Identification of novel, crypticMicrobial genomics · 2022Article
- Article
- Molecular epidemiology ofFrontiers in public health · 2022Article
- Evaluation of an immunochromatographic test for the detection of glutamate dehydrogenase for the diagnosis of Clostridioides (Clostridium) difficile infection in dogs.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Performance of commercial PCR assays to detect toxigenic Clostridioides difficile in the feces of puppies.Veterinary medicine and science · 2021Article
- Complete Genome Sequence of Peptacetobacter (Clostridium) hiranonis Strain DGF055142, Isolated from Dog Feces from Flagstaff, Arizona, USA, 2019.Microbiology resource announcements · 2021Article
- Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota.Anaerobe · 2020Article
- Association of Household Exposure to Primary Clostridioides difficile Infection With Secondary Infection in Family Members.JAMA network open · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nosocomial acquisition of Clostridium difficile is well documented, yet recent studies have highlighted the importance of community acquired infections and identified community associated reservoirs for this pathogen. Multiple studies have implicated companion pets and farm animals as possible sources of community acquired C. difficile infections in humans. To explore the potential role of pet dogs in human C. difficile infections we systematically collected canine fecal samples (n = 197) in Flagstaff, AZ. Additionally, nineteen fecal samples were collected at a local veterinary clinic from diarrheic dogs. We used these combined samples to investigate important questions regarding C. difficile colonization in pet canines: 1) What is the prevalence and diversity of C. difficile in this companion pet population, and 2) Do C. difficile isolates collected from canines genetically overlap with isolates that cause disease in humans? We used a two-step sequence typing approach, including multilocus sequence typing to determine the overall genetic diversity of C. difficile present in Flagstaff canines, and whole-genome sequencing to assess the fine-scale diversity patterns within identical multilocus sequence types from isolates obtained within and among multiple canine hosts. We detected C. difficile in 17% of the canine fecal samples with 10% containing toxigenic strains that are known to cause human disease. Sequencing analyses revealed similar genotypes in dogs and humans. These findings suggest that companion pets are a potential source of community acquired C. difficile infections in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.