ArticleNature genetics2016
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
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Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 368 papers, 4 of them syntheses that pooled it.
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368citing papers in PubMed, 4 pooled it
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Who cites it
368 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effects of Probiotic Supplementation on Core Symptoms of Autism Spectrum Disorder in Children.Nutrients · 2026Pooled it
- Changes in the Firmicutes to Bacteriodetes ratio in the gut microbiome in individuals with anorexia nervosa following inpatient treatment: A systematic review and a case series.Brain and behavior · 2024Pooled it
- Pooled it
- The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies.Nutrients · 2021Pooled it
- Randomized control trial of moderate dose vitamin D alters microbiota stability and metabolite networks in healthy adults.Microbiology spectrum · 2024Trial
- Genetically determined gut microbial abundance and 2-year changes in central adiposity and body composition: The POUNDS lost trial.Clinical nutrition (Edinburgh, Scotland) · 2022Trial
- Pilot Trial of Vitamin D3 and Calcifediol in Healthy Vitamin D Deficient Adults: Does It Change the Fecal Microbiome?The Journal of clinical endocrinology and metabolism · 2021Trial
- Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study.BMC microbiology · 2021Trial
- Genetic Links to Gut Microbiome Variation in the Yellow-Rumped Warbler Hybrid Zone.Molecular ecology · 2026Article
- Common genetic variants in vitamin D metabolism-related genes affect gut microbiota diversity in postmenopausal women.Genes & nutrition · 2026Article
- Integrative host transcriptomic and mucosal microbiome profiling reveals region-specific host-microbiome associations across the human intestine.bioRxiv : the preprint server for biology · 2026Article
- Host genetic variation and gut microbiome in pediatric diseases.Chinese medical journal · 2026Review
- Article
- Genetics-mediated regulation of intestinal gene expression on microbiome contributes to human disease heritability.Molecular systems biology · 2026Article
- The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition.Nature genetics · 2026Article
- Gut microbiome composition and strain-sharing in multiplex autism spectrum disorder families.Nature communications · 2026Article
- Urobiota analysis and genome-wide association study in pediatric recurrent urinary tract infections and vesicoureteral reflux.JCI insight · 2026Article
- Vitamin D Receptor in Cancer: Biological Functions, Mechanistic Insights, and Clinical Relevance.Cancer management and research · 2026Review
- Importance of vitamin D in gastrointestinal health and disease.Frontiers in nutrition · 2026Review
- Article
308 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
39 authors.
Jun WangEvolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Louise B ThingholmInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Jurgita SkiecevičienėInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Philipp RauschEvolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Martin KummenNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo, Norway.
Johannes R HovNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo, Norway.
Frauke DegenhardtInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Femke-Anouska HeinsenInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.ORCID 0000-0003-3652-6402
Malte C RühlemannInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.ORCID 0000-0002-0685-0052
Silke SzymczakInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Kristian HolmNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo, Norway.
Tönu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1982-6569
Jun SunDivision of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7465-3133
Mihaela Pricop-JeckstadtDepartment of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
Samer Al-DuryDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Pavol BohovDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Jörn BethuneInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.ORCID 0000-0002-6919-2595
Felix SommerInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
David EllinghausInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Rolf K BergeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Matthias HübenthalInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.ORCID 0000-0002-5956-3006
Manja KochInstitute of Epidemiology, Christian Albrechts University of Kiel, Kiel, Germany.
Karin SchwarzInstitute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
Gerald RimbachInstitute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
Patricia HübbeInstitute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
Wei-Hung PanInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Raheleh Sheibani-TezerjiInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Robert HäslerInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Philipp RosenstielInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Mauro D'AmatoBioDonostia Health Research Institute, San Sebastian and Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Katja Cloppenborg-SchmidtInstitute for Experimental Medicine, Christian Albrechts University of Kiel, Kiel, Germany.
Sven KünzelEvolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Matthias LaudesDepartment of Internal Medicine I, University Hospital S.-H. (UKSH, Campus Kiel), Kiel, Germany.
Hanns-Ulrich MarschallDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Wolfgang LiebInstitute of Epidemiology, Christian Albrechts University of Kiel, Kiel, Germany.
Ute NöthlingsDepartment of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
Tom H KarlsenNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo, Norway.
John F BainesEvolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
Funding
Vitamin D Receptor Regulation of Microbiota in Intestinal EpitheliaR01DK105118 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUN, JUN · 2016 to 2020
$1.8MEnteric bacterial modulation of Vitamin D Receptor signaling in colitisR03DK089010 · NIDDK · UNIVERSITY OF ROCHESTER · PI SUN, JUN · 2010 to 2011
$154kNIDDK NIH HHS R01 DK105118NIDDK NIH HHS R03 DK089010
Abstract
Human gut microbiota is an important determinant for health and disease, and recent studies emphasize the numerous factors shaping its diversity. Here we performed a genome-wide association study (GWAS) of the gut microbiota using two cohorts from northern Germany totaling 1,812 individuals. Comprehensively controlling for diet and non-genetic parameters, we identify genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci, including the VDR gene (encoding vitamin D receptor). We observe significant shifts in the microbiota of Vdr
Indexed as
Gastrointestinal MicrobiomeAdultAgedAged, 80 and overAnimalsBacteriaCohort StudiesDietFemaleGenome-Wide Association StudyHumansMaleMiceMice, KnockoutMiddle AgedPolymorphism, Single NucleotideReceptors, CalcitriolVDR protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.