Evidence map›Paper›PMID 27723746›Full record

ArticleNature neuroscience2016

Activity flow over resting-state networks shapes cognitive task activations.

Michael W Cole, Takuya Ito, Danielle S Bassett, Douglas H Schultz

Abstract read
In one paragraph

Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Bayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  17. Task context is broadly encoded in the human brain.bioRxiv : the preprint server for biology · 2026
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  18. Article
  19. The Comodification of Brain Activity, Functional Connectivity, and Behavior Following Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  20. Article

215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael W ColeCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA.
Takuya ItoCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA.
Danielle S BassettDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Douglas H SchultzCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Linguistic and NonLinguistic Functions of Frontal CortexR01DC009209 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI THOMPSONSCHILL, SHARON L · 2008 to 2018
$5.2M
Brain Network Mechanisms of Instructed LearningR01MH109520 · NIMH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2016 to 2020
$2.0M
Network Mechanisms of Flexible Cognitive ControlR00MH096801 · NIMH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2014 to 2016
$747k
Evolution of the Linked Architecture of Network Control and Executive Function in AdolescenceR21MH106799 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, SATTERTHWAITE, THEODORE · 2016 to 2017
$515k
CRCNS: US-France Modeling & Predicting BCI Learning from Dynamic NetworksR01HD086888 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH · 2015 to 2018
$506k
NICHD NIH HHS R01 HD086888NIDCD NIH HHS R01 DC009209NIMH NIH HHS R00 MH096801NIMH NIH HHS R01 MH109520NIMH NIH HHS R21 MH106799NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Resting-state functional connectivity (FC) has helped reveal the intrinsic network organization of the human brain, yet its relevance to cognitive task activations has been unclear. Uncertainty remains despite evidence that resting-state FC patterns are highly similar to cognitive task activation patterns. Identifying the distributed processes that shape localized cognitive task activations may help reveal why resting-state FC is so strongly related to cognitive task activations. We found that estimating task-evoked activity flow (the spread of activation amplitudes) over resting-state FC networks allowed prediction of cognitive task activations in a large-scale neural network model. Applying this insight to empirical functional MRI data, we found that cognitive task activations can be predicted in held-out brain regions (and held-out individuals) via estimated activity flow over resting-state FC networks. This suggests that task-evoked activity flow over intrinsic networks is a large-scale mechanism explaining the relevance of resting-state FC to cognitive task activations.

Indexed as

Brain MappingAdultBrainCognitionFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsRest

Identifiers

PMID27723746
PMCPMC5127712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.